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CBX2,CBX4,CBX6,CBX8 [nucleoplasm]
Stable Identifier
R-HSA-9007203
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
Participants
members
CBX2 [nucleoplasm]
(Homo sapiens)
CBX4 [nucleoplasm]
(Homo sapiens)
CBX6 [nucleoplasm]
(Homo sapiens)
CBX8 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
Inferred To
Pc [nucleoplasm]
(Drosophila melanogaster)
CBX2,CBX4,CBX8 [nucleoplasm]
(Danio rerio)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm]
(Bos taurus)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm]
(Canis familiaris)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm]
(Gallus gallus)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm]
(Mus musculus)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm]
(Rattus norvegicus)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm]
(Sus scrofa)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm]
(Xenopus tropicalis)
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