Reactome | KLRC1 [plasma membrane]

KLRC1 [plasma membrane]

Stable Identifier

R-HSA-3006545

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

NKG2-A/NKG2-B type II integral membrane protein, NKG2A_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P26715 KLRC1

Gene Names

KLRC1, NKG2A

Chain

chain:1-233

Reference Genes

BioGPS Gene:3821 KLRC1

COSMIC (genes):KLRC1 KLRC1

CTD Gene:3821 KLRC1

dbSNP Gene:3821 KLRC1

ENSEMBL:ENSG00000134545 KLRC1

ENSEMBL:ENSG00000134545.14 KLRC1

HGNC:6374 KLRC1

KEGG Gene (Homo sapiens):3821 KLRC1

Monarch:3821 KLRC1

NCBI Gene:3821 KLRC1

OMIM:161555 KLRC1

UCSC:P26715 KLRC1

Reference Transcript

Other Identifiers

11731848_s_at

11732927_x_at

16761370

206785_PM_s_at

206785_s_at

32287_s_at

32297_s_at

3444123

3444136

3444139

3444140

3444148

3444149

3444150

3444151

3444152

3444153

3444155

3444156

3444157

3444158

3444159

3444160

3821

7961187

A_23_P139654

A_23_P151046

GE55147

GO:0001915

GO:0002250

GO:0002305

GO:0002376

GO:0002769

GO:0004888

GO:0005515

GO:0005886

GO:0007166

GO:0016020

GO:0023024

GO:0023052

GO:0030154

GO:0030246

GO:0032814

GO:0043235

GO:0045087

GO:0045953

GO:0048856

GO:0060089

GO:0062082

GO:0098542

HMNXSV003027619

HMNXSV003029312

HMNXSV003032816

ILMN_1752647

ILMN_2384139

TC12003273.hg

X54867_s_at

g7108353_3p_s_at

Participates

as a component of

HLA-E interacting with KLRC1:KLRD1 [plasma membrane] (Homo sapiens)

as an input of

KLRC1:KLRD1 heterodimer interacts with HLA-E (Homo sapiens)

Inferred To

LOC100523789 [plasma membrane] (Sus scrofa)

KLRC1 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_002250.1, NP_015567.1, NP_998822.1, NP_998823.1

Guide to Pharmacology - Targets

2849

OpenTargets

ENSG00000134545

HPA

ENSG00000134545-KLRC1

GeneCards

P26715

Ensembl

ENST00000408006, ENSG00000134545, ENSP00000385304, ENSP00000352064, ENST00000544822, ENSP00000256965, ENSP00000438038, ENST00000347831, ENST00000359151

PRO

P26715

Pharos - Targets

P26715

PDB

3BDW, 2YU7, 3CII, 2RMX, 3CDG

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21145 MAL			0.718	6
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.718	6
UniProt:Q13241 KLRD1	1	KLRD1 [plasma membrane] (R-HSA-2326854)	0.676	6
UniProt:Q9UHP7-3 CLEC2D			0.601	4
UniProt:P54852 EMP3			0.601	4
UniProt:Q9NTQ9 GJB4	1	GJB4 [endoplasmic reticulum membrane] (R-HSA-190624)	0.556	3
UniProt:Q9BZJ8 GPR61			0.556	3
UniProt:Q99437 ATP6V0B	3	ATP6V0B [lysosomal membrane] (R-HSA-9640187) ATP6V0B [phagocytic vesicle membrane] (R-HSA-1222695) ATP6V0B [endosome membrane] (R-HSA-912584)	0.556	3
UniProt:Q6ZP80 TM182			0.556	3
UniProt:Q13021 MALL			0.556	3
UniProt:O95183 VAMP5			0.556	3
UniProt:Q8N112 LSME2			0.556	3
UniProt:Q99675 CGRF1			0.556	3
UniProt:P36957 DLST	2	DLST [mitochondrial matrix] (R-HSA-6792574) Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993)	0.556	3
UniProt:P60201-2 PLP1			0.556	3
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3
UniProt:Q8NBI2 CYAC3			0.556	3
UniProt:Q5J8X5 M4A13			0.556	3
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.556	3
UniProt:Q969K7 TMM54			0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:Q5TGU0 TSPO2			0.556	3
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.556	3
UniProt:A0PK11 CLRN2			0.556	3
UniProt:Q6PL45-2 BRICD5			0.556	3
UniProt:Q9BXN2-6 CLEC7A			0.556	3
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.556	3
UniProt:Q15078 CDK5R1	4	MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:P29033 GJB2	3	GJB2 [plasma membrane] (R-HSA-53211) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614)	0.556	3
UniProt:O95452 GJB6	1	GJB6 [endoplasmic reticulum membrane] (R-HSA-190633)	0.556	3
UniProt:Q7Z2K6 ERMP1			0.556	3
UniProt:O75841 UPK1B			0.556	3
UniProt:O95159 ZFPL1			0.556	3
UniProt:E9PQX1 TM262			0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q6ZT21 TMPPE			0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [lysosomal membrane] (R-HSA-9640194) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [endosome membrane] (R-HSA-912591)	0.556	3
UniProt:P27701 CD82			0.556	3
UniProt:Q16617 NKG7			0.556	3
UniProt:O75508 CLDN11	2	CLDN11 [plasma membrane] (R-HSA-420012) CLDN11 [cell junction] (R-HSA-421246)	0.556	3
UniProt:Q96E93 KLRG1	1	KLRG1 [plasma membrane] (R-HSA-198006)	0.556	3
UniProt:P48509 CD151	2	CD151 [cytosol] (R-HSA-446072) CD151 [plasma membrane] (R-HSA-913947)	0.556	3

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