Reactome | KLRD1 [plasma membrane]

KLRD1 [plasma membrane]

Stable Identifier

R-HSA-2326854

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD94, Natural killer cells antigen CD94, KLRD1_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - KLRC1:KLRD1 heterodimer interacts with HLA-E (Homo sapiens)
      - HLA-E interacting with KLRC1:KLRD1 [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - KLRD1 [plasma membrane] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - DAP12 interactions (Homo sapiens)
    - DAP12 interacts with NKG2C (Homo sapiens)
      - CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - HLA-E:CD94:NKG2C:DAP12 [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
    - DAP12 signaling (Homo sapiens)
      - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of BTK by p-SYK (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of DAP12 (Homo sapiens)
        
        DAP12 receptors:DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of LAT by p-SYK (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
        
        p-SYK/p-BTK [plasma membrane] (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of SYK (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - Recruitment of SYK to p-DAP12 (Homo sapiens)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
        
        DAP12 receptors [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
        
        CD94:NKG2C [plasma membrane] (Homo sapiens)
        
        KLRD1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13241 KLRD1

Gene Names

KLRD1, CD94

Chain

chain:1-179

Reference Genes

BioGPS Gene:3824 KLRD1

COSMIC (genes):KLRD1 KLRD1

CTD Gene:3824 KLRD1

dbSNP Gene:3824 KLRD1

ENSEMBL:ENSG00000134539.17 KLRD1

HGNC:6378 KLRD1

KEGG Gene (Homo sapiens):3824 KLRD1

Monarch:3824 KLRD1

NCBI Gene:3824 KLRD1

OMIM:602894 KLRD1

UCSC:Q13241 KLRD1

Reference Transcript

Other Identifiers

11740450_a_at

11740451_a_at

11740452_x_at

11742216_a_at

11753484_x_at

11753534_a_at

11753535_x_at

16748327

207795_PM_s_at

207795_s_at

207796_PM_x_at

207796_x_at

210606_PM_x_at

210606_x_at

33531_at

3404669

3404670

3404671

3404673

3404674

3404676

3404677

3404679

3404680

3404681

3404683

3404684

3404693

3404695

3404697

3564202

3824

7953949

A_14_P113989

A_23_P204208

A_33_P3406196

GE58279

GO:0001915

GO:0002223

GO:0002228

GO:0002250

GO:0002376

GO:0004888

GO:0005515

GO:0005886

GO:0007166

GO:0009897

GO:0016020

GO:0023024

GO:0023030

GO:0023052

GO:0030246

GO:0032814

GO:0043235

GO:0045087

GO:0045953

GO:0045954

GO:0060089

GO:0062082

GO:0098542

GO:1990405

ILMN_1797988

ILMN_1799134

ILMN_2386453

PH_hs_0027119

TC12000160.hg

U30610_at

g2804283_3p_a_at

Participates

as a component of

as an input of

KLRC1:KLRD1 heterodimer interacts with HLA-E (Homo sapiens)

Inferred To

LOC618565 [plasma membrane] (Bos taurus)

Klrd1 [plasma membrane] (Mus musculus)

Klrd1 [plasma membrane] (Rattus norvegicus)

KLRD1 [plasma membrane] (Bos taurus)

KLRD1 [plasma membrane] (Canis familiaris)

KLRD1 [plasma membrane] (Gallus gallus)

KLRD1 [plasma membrane] (Sus scrofa)

Homologues of KLRD1 [plasma membrane] (Bos taurus)

Cross References

RefSeq

NP_031360.1, XP_016874780.1, NP_001107868.1, NP_002253.1

OpenTargets

ENSG00000134539

HPA

ENSG00000134539-KLRD1

GeneCards

Q13241

Ensembl

ENSP00000338130, ENST00000381908, ENSP00000310929, ENSP00000371333, ENSG00000134539, ENST00000350274, ENST00000336164

PRO

Q13241

Pharos - Targets

Q13241

PDB

1B6E, 3BDW, 3CII, 3CDG

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.676	6
UniProt:P26717 KLRC2	1	KLRC2 [plasma membrane] (R-HSA-2159807)	0.609	2

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