KLRC1:KLRD1 heterodimer interacts with HLA-E

Stable Identifier
R-HSA-199062
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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KLRC1:KLRD1 heterodimer interacts with HLA-E
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After interaction with its ligand HLA-E, which is expressed on normal cells, the C-type lectin inhibitory receptor CD94/NKG2A suppresses activation signaling processes. CD94/NKG2A receptors continuously recycle from the cell surface through endosomal compartments and back again in a process that requires energy and the cytoskeleton. This steady state process appears to be largely unaffected by exposure to ligand.
Literature References
PubMed ID Title Journal Year
11513152 Structural basis of MHC class I recognition by natural killer cell receptors

Wang, J, Sawicki, MW, Mariuzza, RA, Natarajan, K, Margulies, DH, Dimasi, N

Immunol Rev 2001
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as an event of
Orthologous Events
KLRC1:KLRD1 heterodimer interacts with HLA-E (Gallus gallus)
Authored
de Bono, B  (2007-07-08)
Reviewed
Barrow, AD  (2015-05-13)
Trowsdale, J  (2007-08-06)
Created
de Bono, B  (2007-07-08)
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