Reactome | GNAO1 [plasma membrane]

GNAO1 [plasma membrane]

Stable Identifier

R-HSA-2997536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G alpha (o), GNAO_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - Ca2+ pathway (Homo sapiens)
      - FZD recruits trimeric G-proteins (Homo sapiens)
        
        Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
      - G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
      - WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09471 GNAO1

Gene Names

GNAO1

Chain

initiator methionine:, chain:2-354

Reference Genes

BioGPS Gene:2775 GNAO1

COSMIC (genes):GNAO1 GNAO1

CTD Gene:2775 GNAO1

dbSNP Gene:2775 GNAO1

ENSEMBL:ENSG00000087258 GNAO1

HGNC:4389 GNAO1

KEGG:hsa:2775 GNAO1

Monarch:2775 GNAO1

NCBI Gene:2775 GNAO1

OMIM:139311 GNAO1

UCSC:P09471 GNAO1

Reference Transcript

Other Identifiers

11733813_a_at

11733814_a_at

11742976_at

11742977_a_at

11756528_x_at

16819161

204762_PM_s_at

204762_s_at

204763_PM_s_at

204763_s_at

215912_PM_at

215912_at

231951_PM_at

231951_at

236_at

2775

34138_at

34698_at

3661941

3661942

3661943

3661944

3661945

3661946

3661947

3661948

3661952

3661966

3661967

3661970

3661979

3661981

3661982

3661983

3661984

3661997

3661999

3662000

3662001

3662005

3662007

3662008

3662009

3662010

3662011

3662012

3662013

3662015

3662016

3662017

3662018

69489_at

7995739

90648_at

91782_f_at

91785_r_at

A_14_P108997

A_14_P130254

A_23_P26582

A_24_P393611

A_24_P936145

A_33_P3404814

GE57855

GE688249

GE80588

GO:0003012

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005737

GO:0005834

GO:0005886

GO:0006904

GO:0006936

GO:0007165

GO:0007186

GO:0007188

GO:0007198

GO:0007212

GO:0007626

GO:0008016

GO:0010854

GO:0016020

GO:0016787

GO:0019001

GO:0030425

GO:0031683

GO:0031821

GO:0031852

GO:0042734

GO:0044297

GO:0045211

GO:0046676

GO:0046872

GO:0051430

GO:0098688

GO:0098772

GO:0098978

GO:0098982

GO:0099170

HMNXSV003036451

HMNXSV003056785

Hs.198511.0.S1_3p_at

Hs.296184.0.S1_3p_a_at

Hs.296184.0.S1_3p_s_at

Hs.296184.1.S1_3p_at

ILMN_1742704

ILMN_1800381

M60165_cds1_at

PH_hs_0023187

PH_hs_0035715

TC16000461.hg

TC16001574.hg

g10567815_3p_a_at

Participates

as a member of

G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)

Inferred To

GNAO1 [plasma membrane] (Bos taurus)

GNAO1 [plasma membrane] (Caenorhabditis elegans)

GNAO1 [plasma membrane] (Canis familiaris)

GNAO1 [plasma membrane] (Drosophila melanogaster)

GNAO1 [plasma membrane] (Gallus gallus)

GNAO1 [plasma membrane] (Rattus norvegicus)

GNAO1 [plasma membrane] (Sus scrofa)

gnao1 [plasma membrane] (Xenopus tropicalis)

Gnao1 [plasma membrane] (Mus musculus)

Cross References

RefSeq

NP_620073.2, NP_066268.1

OpenTargets

ENSG00000087258

ENSEMBL

ENST00000262494, ENST00000638705, ENST00000262493, ENSP00000491223, ENSP00000262494, ENSP00000262493

HPA

ENSG00000087258-GNAO1

ZINC target

P09471

PRO

P09471

Pharos - Targets

P09471

Orphanet

GNAO1

HMDB Protein

HMDBP11470

PDB

8IYH, 8HQC, 7W2Z, 6FUF, 8J6D, 8IA2, 8IED, 7D77, 8JHN, 7W6P, 7T94, 6K41, 8E9X, 7T96, 8IY9, 7D76, 7EJ8, 8HPT, 7T90, 7EJ0, 7T8X, 7EJK, 7EJA, 8I97, 8I95, 8FN1, 8IEC, 7W7E, 8IYW, 7QVM, 6G79, 6OIK, 8DZQ, 7XJJ, 8JZZ, 8I9L, 7Y24, 8I9S, 6WWZ, 8JER

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.556	3
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.556	3