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CTSB(129-333) [extracellular region]
Stable Identifier
R-HSA-2471625
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Cathepsin B heavy chain, CTSB, CATB_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Endostatin degradation by cathepsins (Homo sapiens)
Endostatin-degrading cathepsins [extracellular region] (Homo sapiens)
Cathepsin B dimer [extracellular region] (Homo sapiens)
CTSB(129-333) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07858 CTSB
Gene Names
CTSB, CPSB
Chain
signal peptide:1-17, propeptide:18-79, chain:80-333, chain:80-126, chain:129-333, propeptide:334-339
Reference Genes
BioGPS Gene:1508 CTSB
COSMIC (genes):CTSB CTSB
CTD Gene:1508 CTSB
dbSNP Gene:1508 CTSB
ENSEMBL:ENSG00000164733 CTSB
HGNC:2527 CTSB
KEGG:hsa:1508 CTSB
Monarch:1508 CTSB
NCBI Gene:1508 CTSB
OMIM:116810 CTSB
UCSC:P07858 CTSB
Reference Transcript
RefSeq:NM_001384726.1 CTSB
RefSeq:XM_017013100.1 CTSB
RefSeq:NM_001384727.1 CTSB
RefSeq:XM_006716244.2 CTSB
RefSeq:XM_006716245.2 CTSB
RefSeq:NM_001384728.1 CTSB
RefSeq:XM_011543812.2 CTSB
RefSeq:NM_147783.4 CTSB
RefSeq:NM_001908.5 CTSB
RefSeq:XM_017013099.1 CTSB
RefSeq:XM_017013097.1 CTSB
RefSeq:NM_001384714.1 CTSB
RefSeq:NM_001384725.1 CTSB
RefSeq:NM_147781.4 CTSB
RefSeq:XM_017013098.1 CTSB
RefSeq:NM_001384724.1 CTSB
RefSeq:NM_147780.4 CTSB
RefSeq:NM_147782.4 CTSB
RefSeq:NM_001384723.1 CTSB
Other Identifiers
11716716_x_at
1508
17074673
213275_3p_x_at
213275_PM_x_at
213275_x_at
227961_PM_at
227961_at
243157_PM_at
243157_at
3124538
3124539
3124540
3124541
3124542
3124543
3124555
3124557
3124558
3124560
3124564
3124565
3124566
3124568
3124569
3124577
3124579
3124580
3124581
3124582
3124583
3124584
3124585
3124586
3124587
3124588
3124589
3124590
3124591
3124592
78806_at
A_23_P215944
A_24_P397928
A_33_P3287631
GE87588
GO:0004175
GO:0004197
GO:0005515
GO:0005518
GO:0005576
GO:0005615
GO:0005764
GO:0005886
GO:0006508
GO:0006575
GO:0006590
GO:0008233
GO:0008234
GO:0009897
GO:0016020
GO:0016324
GO:0016787
GO:0030154
GO:0030312
GO:0030574
GO:0030855
GO:0031012
GO:0036021
GO:0042470
GO:0042981
GO:0043394
GO:0046697
GO:0046718
GO:0048471
GO:0048856
GO:0050790
GO:0051603
GO:0070062
GO:0097067
GO:1904090
GO:1904813
HMNXSV003038892
Hs.135226.0.A1_3p_at
Hs.297939.2.A1_3p_at
ILMN_1696360
ILMN_2359742
PH_hs_0031766
TC08000980.hg
p15605
Participates
as a component of
Cathepsin B dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
CTSB(80-333) [endolysosome lumen]
CTSB(80-126) [lysosomal lumen]
CTSB(129-333) [lysosomal lumen]
CTSB(80-333) [ficolin-1-rich granule lumen]
CTSB(80-333) [extracellular region]
CTSB(80-126) [extracellular region]
CTSB(80-333) [lysosomal lumen]
Inferred To
CTSB [extracellular region]
(Bos taurus)
CTSB [extracellular region]
(Canis familiaris)
CTSB [extracellular region]
(Gallus gallus)
CTSB [extracellular region]
(Sus scrofa)
cpr-9 [extracellular region]
(Caenorhabditis elegans)
CtsB [extracellular region]
(Drosophila melanogaster)
Ctsb [extracellular region]
(Mus musculus)
Ctsb [extracellular region]
(Rattus norvegicus)
ctsb [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001371654.1
,
NP_001371652.1
,
NP_001371653.1
,
NP_001899.1
,
XP_006716308.1
,
XP_016868589.1
,
XP_006716307.1
,
NP_001371657.1
,
XP_016868588.1
,
NP_001371656.1
,
XP_011542114.1
,
NP_001371655.1
,
NP_001371643.1
,
NP_680091.1
,
NP_680092.1
,
NP_680090.1
,
XP_016868587.1
,
NP_680093.1
,
XP_016868586.1
ZINC - World Drugs
CATB_HUMAN
Guide to Pharmacology - Targets
2343
OpenTargets
ENSG00000164733
ENSEMBL
ENSP00000518430
,
ENSP00000504336
,
ENSP00000518418
,
ENSP00000504659
,
ENSP00000518443
,
ENST00000710704
,
ENST00000532392
,
ENSP00000518460
,
ENST00000677671
,
ENSP00000518469
,
ENST00000528965
,
ENSP00000433215
,
ENST00000710730
,
ENST00000710732
,
ENSP00000518428
,
ENSP00000518441
,
ENST00000678145
,
ENSP00000435105
,
ENSP00000518450
,
ENSP00000518420
,
ENSP00000518437
,
ENST00000646105
,
ENST00000676843
,
ENSP00000518436
,
ENST00000710725
,
ENST00000710722
,
ENSP00000434725
,
ENSP00000504638
,
ENSP00000503652
,
ENST00000710718
,
ENST00000527215
,
ENSP00000503578
,
ENST00000677366
,
ENST00000710751
,
ENST00000710759
,
ENST00000710713
,
ENSP00000518434
,
ENST00000646239
,
ENSP00000493857
,
ENSP00000518417
,
ENSP00000518442
,
ENST00000531502
,
ENSP00000503006
,
ENST00000710702
,
ENST00000710705
,
ENST00000710747
,
ENST00000710745
,
ENSP00000503078
,
ENSP00000518427
,
ENST00000677418
,
ENSP00000518440
,
ENSP00000435074
,
ENSP00000432408
,
ENST00000678357
,
ENST00000534382
,
ENSP00000503435
,
ENSP00000518457
,
ENST00000676952
,
ENSP00000518452
,
ENST00000531089
,
ENSP00000433929
,
ENSP00000518432
,
ENST00000679051
,
ENSP00000518464
,
ENST00000710720
,
ENSP00000435260
,
ENST00000710763
,
ENST00000710727
,
ENSG00000164733
,
ENSP00000504226
,
ENST00000710719
,
ENST00000526645
,
ENST00000710716
,
ENST00000678929
,
ENST00000710714
,
ENST00000676825
,
ENSP00000518433
,
ENST00000530640
,
ENST00000530296
,
ENSP00000518419
,
ENSP00000503909
,
ENST00000679128
,
ENSP00000518445
,
ENST00000710703
,
ENST00000710743
,
ENST00000710700
,
ENSP00000504480
,
ENSP00000518468
,
ENSP00000518426
,
ENSP00000518456
,
ENSP00000432244
,
ENSP00000431518
,
ENST00000677082
,
ENSP00000503674
,
ENST00000710731
,
ENSP00000431143
,
ENSP00000503513
,
ENST00000533455
,
ENST00000534510
,
ENST00000676755
,
ENSP00000518435
,
ENST00000527243
,
ENST00000678242
,
ENSP00000518421
,
ENST00000679140
,
ENST00000678092
,
ENST00000710721
,
ENST00000710764
,
ENSP00000494729
,
ENST00000710723
,
ENSP00000503174
,
ENST00000710728
,
ENSP00000504797
,
ENSP00000518449
,
ENST00000677873
,
ENST00000710752
,
ENSP00000503280
,
ENST00000676691
,
ENST00000353047
,
ENSP00000503858
,
ENSP00000503487
,
ENST00000677544
,
ENSP00000518444
,
ENSG00000285132
,
ENSP00000518448
,
ENST00000710744
,
ENSP00000504161
,
ENSP00000345672
,
ENSP00000503608
,
ENSP00000435886
,
ENSP00000433379
,
ENSP00000518455
,
ENSP00000518429
,
ENSP00000342070
,
ENSP00000434217
,
ENST00000677819
,
ENST00000677650
,
ENSP00000503052
,
ENST00000532656
,
ENST00000677415
,
ENST00000345125
,
ENSP00000518438
,
ENSP00000518466
,
ENST00000710761
,
ENST00000678615
,
ENST00000710724
,
ENST00000710729
,
ENSP00000503300
,
ENST00000710717
,
ENST00000710715
,
ENSP00000502963
,
ENST00000710755
,
ENST00000710750
,
ENSP00000518431
ZINC - FDA approved
CATB_HUMAN
ZINC - Substances
CATB_HUMAN
ZINC - Biogenic
CATB_HUMAN
ZINC target
P07858
PRO
P07858
GlyGen
P07858
PDB
1CSB
,
1GMY
,
1HUC
,
2PBH
,
1PBH
,
5MBL
,
8B4T
,
3PBH
,
5MBM
,
3K9M
,
8B5F
,
8HEN
,
3CBK
,
3AI8
,
8HE9
,
6AY2
,
8HEI
,
2IPP
,
3CBJ
ZINC - Investigational
CATB_HUMAN
ZINC - Metabolites
CATB_HUMAN
IntEnz
3.4.22.1
GeneCards
CTSB
HPA
ENSG00000164733-CTSB
Pharos - Targets
P07858
Orphanet
CTSB
ZINC - Predictions - Purchasable
CATB_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40692 MLH1
3
MLH1 [nucleoplasm]
(R-HSA-912495)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
0.602
6
UniProt:P02760 AMBP
3
AMBP(20-202) [extracellular region]
(R-HSA-2168853)
AMBP(20-198) [extracellular region]
(R-HSA-2168855)
thioether crosslinked C53-AMBP(20-202) [extracellular region]
(R-HSA-2203514)
0.602
4
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