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CTSB(80-333) [extracellular region]
Stable Identifier
R-HSA-6801608
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Cathepsin B, CTSB, CATB_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
CTSB(80-333) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07858 CTSB
Gene Names
CTSB, CPSB
Chain
signal peptide:1-17, propeptide:18-79, chain:80-333, chain:80-126, chain:129-333, propeptide:334-339
Reference Genes
BioGPS Gene:1508 CTSB
COSMIC (genes):CTSB CTSB
CTD Gene:1508 CTSB
dbSNP Gene:1508 CTSB
ENSEMBL:ENSG00000164733 CTSB
ENSEMBL_homo_sapiens_GENE:ENSG00000164733.23 CTSB
ENSEMBL_homo_sapiens_GENE:ENSG00000285132.3 CTSB
HGNC:2527 CTSB
KEGG Gene (Homo sapiens):1508 CTSB
Monarch:1508 CTSB
NCBI Gene:1508 CTSB
OMIM:116810 CTSB
UCSC:P07858 CTSB
Reference Transcript
RefSeq:NM_147780.3 CTSB
RefSeq:NM_147782.3 CTSB
RefSeq:XM_006716244.2 CTSB
RefSeq:XM_011543812.2 CTSB
RefSeq:NM_001908.4 CTSB
RefSeq:NM_147781.3 CTSB
RefSeq:XM_017013098.1 CTSB
RefSeq:NM_147783.3 CTSB
RefSeq:XM_006716245.2 CTSB
RefSeq:XM_017013100.1 CTSB
RefSeq:XM_017013097.1 CTSB
RefSeq:XM_017013099.1 CTSB
Other Identifiers
11716715_a_at
11716716_x_at
11754977_x_at
11756947_a_at
1508
17074673
200838_PM_at
200838_at
200839_PM_s_at
200839_s_at
213275_3p_x_at
213275_PM_x_at
213275_x_at
227961_PM_at
227961_at
243157_at
3124538
3124539
3124540
3124541
3124542
3124543
3124544
3124550
3124551
3124552
3124553
3124554
3124556
3124559
3124561
3124562
3124563
3124567
3124570
3124574
3124576
3124577
3124579
3124582
3124583
3124584
3124585
3124586
3124589
3124590
3124591
3124592
3124593
78806_at
8149330
A_23_P215944
A_24_P397928
A_33_P3287631
GE87588
GO:0003824
GO:0004175
GO:0004197
GO:0005515
GO:0005518
GO:0005576
GO:0005615
GO:0005764
GO:0005768
GO:0005773
GO:0005886
GO:0006508
GO:0006575
GO:0006590
GO:0008233
GO:0008234
GO:0009897
GO:0012501
GO:0016020
GO:0016324
GO:0016787
GO:0022414
GO:0030154
GO:0030163
GO:0030312
GO:0030574
GO:0030855
GO:0031012
GO:0031410
GO:0036021
GO:0042470
GO:0042981
GO:0043226
GO:0043394
GO:0046697
GO:0046718
GO:0048471
GO:0048856
GO:0050790
GO:0051603
GO:0062023
GO:0070062
GO:0097067
GO:0140096
GO:1904090
GO:1904813
HMNXSV003038892
Hs.297939.2.A1_3p_at
ILMN_1696360
ILMN_2359742
PH_hs_0031766
TC08000980.hg
g4503138_3p_a_at
Participates
as a member of
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
CTSB(80-333) [lysosomal lumen]
CTSB(129-333) [extracellular region]
CTSB(80-126) [extracellular region]
CTSB(80-333) [ficolin-1-rich granule lumen]
CTSB(80-333) [endolysosome lumen]
Inferred To
CTSB [extracellular region]
(Bos taurus)
CTSB [extracellular region]
(Canis familiaris)
CTSB [extracellular region]
(Sus scrofa)
cpr-9 [extracellular region]
(Caenorhabditis elegans)
CtsB [extracellular region]
(Drosophila melanogaster)
CTSB(80-333) [extracellular region]
(Gallus gallus)
CTSB(80-333) [extracellular region]
(Plasmodium falciparum)
ctsba [extracellular region]
(Danio rerio)
Ctsb [extracellular region]
(Mus musculus)
Ctsb [extracellular region]
(Rattus norvegicus)
ctsB [extracellular region]
(Dictyostelium discoideum)
ctsb [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016868586.1
,
XP_016868588.1
,
XP_011542114.1
,
XP_016868587.1
,
NP_001899.1
,
XP_016868589.1
,
NP_680091.1
,
XP_006716307.1
,
NP_680092.1
,
XP_006716308.1
,
NP_680093.1
,
NP_680090.1
ZINC - World Drugs
CATB_HUMAN
Guide to Pharmacology - Targets
2343
OpenTargets
ENSG00000164733
ZINC - FDA approved
CATB_HUMAN
ZINC - Substances
CATB_HUMAN
ZINC - Biogenic
CATB_HUMAN
ZINC target
P07858
PRO
P07858
PDB
1HUC
,
8HEI
,
2IPP
,
1GMY
,
1CSB
,
1PBH
,
3CBK
,
5MBM
,
6AY2
,
8B5F
,
8B4T
,
3AI8
,
8HE9
,
8HEN
,
3K9M
,
3CBJ
,
5MBL
,
3PBH
,
2PBH
ZINC - Investigational
CATB_HUMAN
ZINC - Metabolites
CATB_HUMAN
IntEnz
3.4.22.1
HPA
ENSG00000164733-CTSB
GeneCards
P07858
Ensembl
ENSP00000435105
,
ENST00000677819
,
ENSP00000433929
,
ENST00000530640
,
ENST00000677418
,
ENSP00000435074
,
ENSP00000503435
,
ENST00000679140
,
ENST00000678092
,
ENST00000677082
,
ENSP00000503674
,
ENST00000527243
,
ENSP00000504161
,
ENST00000531502
,
ENSP00000503006
,
ENST00000677650
,
ENST00000676755
,
ENST00000530296
,
ENSP00000504659
,
ENST00000678615
,
ENST00000646105
,
ENST00000534382
,
ENST00000678929
,
ENSP00000493857
,
ENST00000526645
,
ENSP00000503909
,
ENSP00000503487
,
ENSP00000504336
,
ENST00000676691
,
ENSP00000503652
,
ENSP00000504226
,
ENST00000353047
,
ENST00000533455
,
ENSP00000503578
,
ENSG00000164733
,
ENST00000532656
,
ENST00000677873
,
ENSP00000433215
,
ENSP00000503280
,
ENSP00000433379
,
ENSP00000435886
,
ENST00000345125
,
ENST00000534510
,
ENST00000679128
,
ENSP00000503174
,
ENST00000678357
,
ENST00000528965
,
ENSP00000503513
,
ENSP00000434217
,
ENSP00000345672
,
ENSP00000504480
,
ENST00000676843
,
ENSP00000503608
,
ENSP00000432408
,
ENSG00000285132
,
ENST00000678242
,
ENST00000677415
,
ENSP00000431143
,
ENSP00000342070
,
ENSP00000431518
,
ENSP00000435260
,
ENST00000646239
,
ENSP00000503078
,
ENST00000679051
,
ENST00000678145
,
ENST00000676825
,
ENSP00000503858
,
ENST00000676952
,
ENST00000532392
,
ENST00000527215
,
ENSP00000504638
,
ENSP00000432244
,
ENST00000677366
,
ENSP00000434725
,
ENSP00000502963
,
ENST00000677544
,
ENST00000531089
,
ENSP00000503052
,
ENSP00000503300
,
ENSP00000494729
,
ENST00000677671
,
ENSP00000504797
Pharos - Targets
P07858
ZINC - Predictions - Purchasable
CATB_HUMAN
Orphanet
25469
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.602
6
UniProt:P02760 AMBP
3
AMBP(20-198) [extracellular region]
(R-HSA-2168855)
thioether crosslinked C53-AMBP(20-202) [extracellular region]
(R-HSA-2203514)
AMBP(20-202) [extracellular region]
(R-HSA-2168853)
0.602
4
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