Reactome | AMBP(20-202) [extracellular region]

AMBP(20-202) [extracellular region]

Stable Identifier

R-HSA-2168853

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Alpha1-Microglobulin, Protein AMBP component recommendedName: Alpha-1-microglobulin, AMBP, AMBP_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
11877257	Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties Allhorn, M, Berggård, T, Nordberg, J, Olsson, ML, Akerström, B	Blood	2002

External Reference Information

External Reference

UniProt:P02760 AMBP

Gene Names

AMBP, HCP, ITIL

Chain

signal peptide:1-19, chain:20-203, chain:206-352, chain:284-344

Reference Genes

BioGPS Gene:259 AMBP

COSMIC (genes):AMBP AMBP

CTD Gene:259 AMBP

dbSNP Gene:259 AMBP

ENSEMBL:ENSG00000106927 AMBP

ENSEMBL_homo_sapiens_GENE:ENSG00000106927.12 AMBP

HGNC:453 AMBP

KEGG Gene (Homo sapiens):259 AMBP

Monarch:259 AMBP

NCBI Gene:259 AMBP

OMIM:176870 AMBP

UCSC:P02760 AMBP

Reference Transcript

RefSeq:NM_001633.3 AMBP

Other Identifiers

11724511_a_at

11747103_a_at

17097512

205477_PM_s_at

205477_s_at

259

3221801

3221802

3221805

3221807

3221808

3221811

3221812

3221814

3221815

3221816

3221817

3221818

36995_at

8163535

A_23_P256504

GE60517

GO:0002376

GO:0003824

GO:0004867

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005737

GO:0005739

GO:0005743

GO:0005783

GO:0005829

GO:0005886

GO:0007155

GO:0007565

GO:0009986

GO:0016020

GO:0016491

GO:0019855

GO:0019862

GO:0020037

GO:0022414

GO:0023052

GO:0030246

GO:0030312

GO:0030414

GO:0031012

GO:0031965

GO:0042167

GO:0042803

GO:0043226

GO:0046329

GO:0046904

GO:0050777

GO:0062023

GO:0070062

GO:0072562

GO:0098772

HMNXSV003033683

ILMN_1695446

PH_hs_0004395

TC09001506.hg

g4502066_3p_at

g4502066_3p_x_at

Participates

as a component of

Alpha1-Microglobulin:heme [extracellular region] (Homo sapiens)

as an input of

Alpha1-Microglobulin binds heme (Homo sapiens)

Other forms of this molecule

AMBP(20-198) [extracellular region]

thioether crosslinked C53-AMBP(20-202) [extracellular region]

Inferred To

AMBP [extracellular region] (Canis familiaris)

AMBP [extracellular region] (Sus scrofa)

AMBP(20-202) [extracellular region] (Gallus gallus)

AMBP(20-202) [extracellular region] (Mus musculus)

AMBP(20-202) [extracellular region] (Rattus norvegicus)

ambp [extracellular region] (Danio rerio)

ambp [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001624.1

OpenTargets

ENSG00000106927

GeneCards

P02760

HPA

ENSG00000106927-AMBP

Ensembl

ENST00000265132, ENSP00000265132, ENSG00000106927

PRO

P02760

Pharos - Targets

P02760

HMDB Protein

HMDBP01676

PDB

6EJC, 3QKG, 4ES7, 4U30, 6EJB, 6EJ8, 6EJ7, 6EJD, 1BIK, 6EJ9, 6EJA

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07858 CTSB	6	CTSB(80-333) [lysosomal lumen] (R-HSA-1181222) CTSB(129-333) [extracellular region] (R-HSA-2471625) CTSB(80-126) [extracellular region] (R-HSA-2228661) CTSB(80-333) [extracellular region] (R-HSA-6801608) CTSB(80-333) [ficolin-1-rich granule lumen] (R-HSA-6801299) CTSB(80-333) [endolysosome lumen] (R-HSA-1679058)	0.602	4
UniProt:Q13643 FHL3			0.556	3
UniProt:P69616 ORF3			0.527	4