Reactome | PDS5A [chromosome, centromeric region]

PDS5A [chromosome, centromeric region]

Stable Identifier

R-HSA-2468259

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome, centromeric region

Synonyms

Sister chromatid cohesion protein PDS5 homolog A, PDS5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Establishment of Sister Chromatid Cohesion (Homo sapiens)
      - CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5A [chromosome, centromeric region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q29RF7 PDS5A

Gene Names

PDS5A, KIAA0648, PDS5, PIG54

Chain

chain:1-1337

Reference Genes

BioGPS Gene:23244 PDS5A

COSMIC (genes):PDS5A PDS5A

CTD Gene:23244 PDS5A

dbSNP Gene:23244 PDS5A

ENSEMBL:ENSG00000121892.15 PDS5A

HGNC:29088 PDS5A

KEGG Gene (Homo sapiens):23244 PDS5A

Monarch:23244 PDS5A

NCBI Gene:23244 PDS5A

OMIM:613200 PDS5A

UCSC:Q29RF7 PDS5A

Reference Transcript

Other Identifiers

11717182_a_at

11717183_a_at

11726842_a_at

11737960_a_at

11764202_at

16975345

212138_PM_at

212138_at

212140_PM_at

212140_at

213983_PM_s_at

213983_s_at

213984_PM_at

213984_at

23244

2766593

2766594

2766595

2766596

2766597

2766598

2766599

2766608

2766609

2766610

2766611

2766614

2766615

2766616

2766620

2766621

2766623

2766624

2766628

2766629

2766631

2766632

2766633

2766634

2766637

2766639

2766642

2766643

2766644

2766645

2766646

2766647

2766648

2766649

2766651

2766652

2766655

2766656

2766658

2766661

2766662

2766664

2766665

2766666

2766667

2766669

2766683

2766684

2766685

2766686

2766687

2766688

2766694

34353_at

74513_at

8099926

A_23_P144294

A_24_P186216

A_24_P52004

GE53359

GE846093

GE85303

GO:0000278

GO:0000775

GO:0000785

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0005886

GO:0006260

GO:0007049

GO:0007059

GO:0007064

GO:0008156

GO:0043226

GO:0051301

GO:0140014

HMNXSV003003914

HMNXSV003004169

Hs.31921.0.S1_3p_at

Hs.31921.0.S1_3p_x_at

Hs.31921.1.S1_3p_at

Hs.31921.1.S2_3p_at

ILMN_1670931

PH_hs_0002712

TC04001134.hg

TC04002521.hg

Participates

as a member of

PDS5 [chromosome, centromeric region] (Homo sapiens)

Other forms of this molecule

PDS5A [cytosol]

PDS5A [chromosome]

PDS5A [nucleoplasm]

Inferred To

evl-14 [chromosome, centromeric region] (Caenorhabditis elegans)

PDS5A [chromosome, centromeric region] (Bos taurus)

PDS5A [chromosome, centromeric region] (Canis familiaris)

PDS5A [chromosome, centromeric region] (Gallus gallus)

PDS5A [chromosome, centromeric region] (Sus scrofa)

pds5 [chromosome, centromeric region] (Dictyostelium discoideum)

pds5 [chromosome, centromeric region] (Drosophila melanogaster)

pds5 [chromosome, centromeric region] (Schizosaccharomyces pombe)

pds5a [chromosome, centromeric region] (Danio rerio)

pds5a [chromosome, centromeric region] (Xenopus tropicalis)

PDS5 [chromosome, centromeric region] (Saccharomyces cerevisiae)

Pds5a [chromosome, centromeric region] (Mus musculus)

Pds5a [chromosome, centromeric region] (Rattus norvegicus)

Cross References

RefSeq

NP_001093870.1, XP_016863417.1, NP_001093869.1, XP_011511974.1

OpenTargets

ENSG00000121892

HPA

ENSG00000121892-PDS5A

GeneCards

Q29RF7

Ensembl

ENSG00000121892, ENST00000303538, ENSP00000303427, ENST00000503396, ENSP00000426749

PRO

Q29RF7

Pharos - Targets

Q29RF7

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.813	9
UniProt:O60216 RAD21	14	monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) RAD21 [cytosol] (R-HSA-2484795) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21(173-450) [cytosol] (R-HSA-2500308) RAD21(1-172) [cytosol] (R-HSA-2484901) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163)	0.813	5
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.642	4
UniProt:Q61550 Rad21	15	Rad21 [nucleoplasm] (R-MMU-3108183) Double-strand-break repair protein rad21 homolog [nucleoplasm] (R-MMU-912350) Rad21 [chromosome, centromeric region] (R-MMU-2500296) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2467790) Rad21 [chromosome, centromeric region] (R-MMU-2467793) Rad21 [cytosol] (R-MMU-2484795) phospho-Rad21 [cytosol] (R-MMU-2500309) Rad21 [cytosol] (R-MMU-2500308) Rad21 [cytosol] (R-MMU-2484901) phospho-Rad21 [cytosol] (R-MMU-2500310) phospho-Rad21 [chromosome] (R-MMU-2485164) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2485163) Rad21 [chromosome] (R-MMU-1638775) Rad21 [chromosome, centromeric region] (R-MMU-2466012) Rad21 [nucleoplasm] (R-MMU-163042)	0.564	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2