Reactome | PDS5A [chromosome]

PDS5A [chromosome]

Stable Identifier

R-HSA-2466360

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome

Synonyms

Sister chromatid cohesion protein PDS5 homolog A, PDS5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Homo sapiens)
        
        Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        PDS5 [chromosome] (Homo sapiens)
        
        PDS5A [chromosome] (Homo sapiens)
        
        Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        PDS5 [chromosome] (Homo sapiens)
        
        PDS5A [chromosome] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at chromosomal arms (Homo sapiens)
        
        Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        PDS5 [chromosome] (Homo sapiens)
        
        PDS5A [chromosome] (Homo sapiens)
        
        Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        PDS5 [chromosome] (Homo sapiens)
        
        PDS5A [chromosome] (Homo sapiens)
        
        Resolution of sister chromatids (Homo sapiens)
        
        Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        PDS5 [chromosome] (Homo sapiens)
        
        PDS5A [chromosome] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Establishment of Sister Chromatid Cohesion (Homo sapiens)
      - CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Homo sapiens)
        
        Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome] (Homo sapiens)
        
        PDS5 [chromosome] (Homo sapiens)
        
        PDS5A [chromosome] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q29RF7 PDS5A

Gene Names

PDS5A, KIAA0648, PDS5, PIG54

Chain

chain:1-1337

Reference Genes

BioGPS Gene:23244 PDS5A

COSMIC (genes):PDS5A PDS5A

CTD Gene:23244 PDS5A

dbSNP Gene:23244 PDS5A

ENSEMBL:ENSG00000121892 PDS5A

HGNC:29088 PDS5A

KEGG Gene (Homo sapiens):23244 PDS5A

Monarch:23244 PDS5A

NCBI Gene:23244 PDS5A

OMIM:613200 PDS5A

UCSC:Q29RF7 PDS5A

Reference Transcript

Other Identifiers

0003140204

11717182_a_at

11717183_a_at

11726842_a_at

11737960_a_at

11764202_at

16975345

212138_at

212140_at

213983_s_at

213984_at

23244

2766593

2766594

2766595

2766596

2766597

2766598

2766599

2766608

2766609

2766610

2766611

2766614

2766615

2766616

2766620

2766621

2766623

2766624

2766628

2766629

2766631

2766632

2766633

2766634

2766637

2766639

2766642

2766643

2766644

2766645

2766646

2766647

2766648

2766649

2766651

2766652

2766655

2766656

2766658

2766661

2766662

2766664

2766665

2766666

2766667

2766669

2766683

2766684

2766685

2766686

2766687

2766688

2766694

34353_at

36661

36662

74513_at

8099926

A_23_P144294

A_24_P186216

A_24_P52004

AAH41361

AAI14219

AAI26226

AAM82347

AAT52214

AB014548

AB621803

AF294791

AK098331

AY550968

BAA31623

BAC05286

BAK64139

BC041361

BC114218

BC126225

CAH18263

CCDS47045

CCDS54759

CH471069

CR749425

EAW92953

ENSG00000121892

ENSP00000303427

ENSP00000426749

ENST00000303538

ENST00000303538.12

ENST00000503396

ENST00000503396.5

EntrezGene:23244

EntrezGene:PDS5A

G1UI16

GE53359

GE846093

GE85303

GO:0000278

GO:0000775

GO:0000785

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006259

GO:0006281

GO:0006950

GO:0007049

GO:0007059

GO:0007064

GO:0008150

GO:0008156

GO:0009058

GO:0034641

GO:0043226

GO:0051276

GO:0051301

GO:0140014

H0Y9L6

H0Y9X6

HGNC:29088

HPA036661

HPA036662

Hs.31921.0.S1_3p_at

Hs.31921.0.S1_3p_x_at

Hs.31921.1.S1_3p_at

Hs.31921.1.S2_3p_at

ILMN_1670931

ILMN_1701069

IPR011989

IPR016024

IPR039776

MIM:613200

NM_001100399

NM_001100400

NP_001093869

NP_001093870

PDS5A

PDS5A-201

PDS5A-202

PH_hs_0002712

TC04001134.hg

TC04002521.hg

UPI000000D9A5

UPI00006C6A7E

XM_011513672

XM_017007928

XP_011511974

XP_016863417

XR_001741184

XR_001741185

XR_001741186

XR_001741187

XR_001741188

Participant Of

hasMember

PDS5 [chromosome]

Other forms of this molecule

PDS5A [cytosol]

PDS5A [chromosome, centromeric region]

PDS5A [nucleoplasm]

Inferred To

PDS5 [chromosome] (Saccharomyces cerevisiae)

evl-14 [chromosome] (Caenorhabditis elegans)

pds5a [chromosome] (Danio rerio)

pds5a [chromosome] (Xenopus tropicalis)

PDS5A [chromosome] (Bos taurus)

PDS5A [chromosome] (Canis familiaris)

PDS5A [chromosome] (Gallus gallus)

PDS5A [chromosome] (Sus scrofa)

Pds5a [chromosome] (Mus musculus)

Pds5a [chromosome] (Rattus norvegicus)

pds5 [chromosome] (Dictyostelium discoideum)

pds5 [chromosome] (Drosophila melanogaster)

pds5 [chromosome] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001093870.1, XP_016863417.1, XP_011511974.1, NP_001093869.1

OpenTargets

ENSG00000121892

HPA

ENSG00000121892-PDS5A

GeneCards

Q29RF7

Ensembl

ENSP00000303427, ENST00000503396, ENSP00000426749, ENSG00000121892, ENST00000303538

PRO

Q29RF7

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	RAD21 [nucleoplasm] (R-HSA-163042) SUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183) RAD21 [chromosome] (R-HSA-1638775) RAD21 [chromosome, centromeric region] (R-HSA-2466012) p-S454-RAD21 [chromosome] (R-HSA-2485164) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [cytosol] (R-HSA-2500308) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21 [cytosol] (R-HSA-2484795)	0.813	5
UniProt:Q7Z5K2 WAPL	4	WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [nucleoplasm] (R-HSA-2466355)	0.813	9
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.642	4
UniProt:Q61550 Rad21	15	Double-strand-break repair protein rad21 homolog [nucleoplasm] (R-MMU-912350) Rad21 [nucleoplasm] (R-MMU-3108183) Rad21 [cytosol] (R-MMU-2484795) phospho-Rad21 [cytosol] (R-MMU-2500309) Rad21 [cytosol] (R-MMU-2500308) Rad21 [cytosol] (R-MMU-2484901) Rad21 [chromosome, centromeric region] (R-MMU-2500296) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2467790) Rad21 [chromosome, centromeric region] (R-MMU-2467793) phospho-Rad21 [chromosome, centromeric region] (R-MMU-2485163) phospho-Rad21 [cytosol] (R-MMU-2500310) phospho-Rad21 [chromosome] (R-MMU-2485164) Rad21 [chromosome, centromeric region] (R-MMU-2466012) Rad21 [chromosome] (R-MMU-1638775) Rad21 [nucleoplasm] (R-MMU-163042)	0.564	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2