Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). Phosphorylated SHC then binds GRB:SOS, which activates RAS-RAF-MAPK signaling.
Knezević, J, Matijević, T, Pavelić, J
Siddle, K
Maki, RG
Longo, VD, Parrella, E
Chitnis, MM, Macaulay, VM, Protheroe, AS, Pollak, M, Yuen, JS
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