SHC-related events triggered by IGF1R

Stable Identifier
Homo sapiens
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Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). Phosphorylated SHC then binds GRB:SOS, which activates RAS-RAF-MAPK signaling.

Literature References
PubMed ID Title Journal Year
20098959 Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain

Parrella, E, Longo, VD

ScientificWorldJournal 2010
22649417 Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances

Siddle, K

Front Endocrinol (Lausanne) 2012
20975071 Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer

Maki, RG

J. Clin. Oncol. 2010
17598937 Biological & physiological aspects of action of insulin-like growth factor peptide family

Pavelić, J, Matijević, T, Knezević, J

Indian J. Med. Res. 2007
18927274 The type 1 insulin-like growth factor receptor pathway

Chitnis, MM, Yuen, JS, Protheroe, AS, Pollak, M, Macaulay, VM

Clin. Cancer Res. 2008
Participant Of
Orthologous Events
Cross References
BioModels Database
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