p-3Y-SHC1 dissociates from IGF1R

Stable Identifier
R-HSA-5686072
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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p-3Y-SHC1 dissociates from IGF1R
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Release of tyrosine-phosphorylated SHC from IGF1R triggers a cascade of signalling events via SOS, RAF and the MAP kinases.

Literature References
PubMed ID Title Journal Year
9852124 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Kim, B, Cheng, HL, Margolis, B, Feldman, EL

J. Biol. Chem. 1998
8033892 Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

Giorgetti, S, Pelicci, PG, Pelicci, G, Van Obberghen, E

Eur. J. Biochem. 1994
7493944 The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis

Hernández-Sánchez, C, Blakesley, V, Kalebic, T, Helman, L, LeRoith, D

J. Biol. Chem. 1995
Participants
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Output
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Orthologous Events
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p-3Y-SHC1 dissociates from IGF1R (Mus musculus)
p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)
p-3Y-SHC1 dissociates from IGF1R (Xenopus tropicalis)
Authored
Jupe, S  (2015-03-31)
Created
Jupe, S  (2015-03-31)