p-3Y-SHC1 dissociates from IGF1R

Stable Identifier
R-HSA-5686072
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-3Y-SHC1 dissociates from IGF1R
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Release of tyrosine-phosphorylated SHC from IGF1R triggers a cascade of signalling events via SOS, RAF and the MAP kinases.

Literature References
PubMed ID Title Journal Year
9852124 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Kim, B, Cheng, HL, Margolis, B, Feldman, EL

J. Biol. Chem. 1998
8033892 Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

Giorgetti, S, Pelicci, PG, Pelicci, G, Van Obberghen, E

Eur. J. Biochem. 1994
7493944 The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis

Hernández-Sánchez, C, Blakesley, V, Kalebic, T, Helman, L, LeRoith, D

J. Biol. Chem. 1995
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
p-3Y-SHC1 dissociates from IGF1R (Canis familiaris)
p-3Y-SHC1 dissociates from IGF1R (Danio rerio)
p-3Y-SHC1 dissociates from IGF1R (Gallus gallus)
p-3Y-SHC1 dissociates from IGF1R (Mus musculus)
p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)
p-3Y-SHC1 dissociates from IGF1R (Xenopus tropicalis)
Authored
Jupe, S  (2015-03-31)
Created
Jupe, S  (2015-03-31)
Cite Us!