GRB2-1:SOS1 binds p-3Y-SHC1

Stable Identifier
Reaction [binding]
Homo sapiens
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Phosphorylated SHC1 recruits the SH2 domain of the adaptor protein GRB2, which is in a complex with SOS, an exchange factor for p21ras and RAC. Besides SOS, the GRB2 SH3 domain can associate with other intracellular targets, including GAB1. Erk and Rsk mediated phosphorylation results in dissociation of the SOS-GRB2 complex. This may explain why Erk activation through Shc and SOS-GRB2 is transient. Inactive p21ras-GDP is found anchored to the plasma membrane by a farnesyl residue. As Shc is phosphorylated by the the stimulated receptor near to the plasma membrane, the SOS-GRB2:Shc interaction brings the SOS enzyme into close proximity to p21ras.

Participant Of
Orthologous Events
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