IGF1R phosphorylates SHC1

Stable Identifier
R-HSA-2404193
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IGF1R phosphorylates SHC1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The phosphorylated IGF1R phosphorylates SHC1 (Giorgetti et al. 1994, Hernandez-Sanchez et al. 1995, Kim et al. 1998). Phosphorylation of SHC1 is sustained whereas phosphorylation of IRS2 by IGF1R is transient (Kim et al. 1998).

Literature References
PubMed ID Title Journal Year
9852124 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Feldman, EL, Cheng, HL, Margolis, B, Kim, B

J. Biol. Chem. 1998
8033892 Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

Pelicci, G, Pelicci, PG, Van Obberghen, E, Giorgetti, S

Eur. J. Biochem. 1994
7493944 The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis

Kalebic, T, Blakesley, V, LeRoith, D, Hernández-Sánchez, C, Helman, L

J. Biol. Chem. 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane]

Physical Entity
IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
IGF1R phosphorylates SHC1 (Canis familiaris)
IGF1R phosphorylates SHC1 (Danio rerio)
IGF1R phosphorylates SHC1 (Gallus gallus)
IGF1R phosphorylates SHC1 (Mus musculus)
IGF1R phosphorylates SHC1 (Rattus norvegicus)
IGF1R phosphorylates SHC1 (Xenopus tropicalis)
Authored
May, B  (2012-07-08)
Reviewed
Holzenberger, M  (2012-11-10)
Created
May, B  (2012-07-16)
Cite Us!