The phosphorylated IGF1R phosphorylates SHC1 (Giorgetti et al. 1994, Hernandez-Sanchez et al. 1995, Kim et al. 1998). Phosphorylation of SHC1 is sustained whereas phosphorylation of IRS2 by IGF1R is transient (Kim et al. 1998).
Pelicci, G, Pelicci, PG, Van Obberghen, E, Giorgetti, S
Feldman, EL, Cheng, HL, Margolis, B, Kim, B
Kalebic, T, Blakesley, V, LeRoith, D, Hernández-Sánchez, C, Helman, L
protein tyrosine kinase activity of IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane]
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