IGF1R phosphorylates SHC1

Stable Identifier
R-HSA-2404193
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The phosphorylated IGF1R phosphorylates SHC1 (Giorgetti et al. 1994, Hernandez-Sanchez et al. 1995, Kim et al. 1998). Phosphorylation of SHC1 is sustained whereas phosphorylation of IRS2 by IGF1R is transient (Kim et al. 1998).

Literature References
PubMed ID Title Journal Year
9852124 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Feldman, EL, Cheng, HL, Margolis, B, Kim, B

J. Biol. Chem. 1998
8033892 Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

Pelicci, G, Pelicci, PG, Van Obberghen, E, Giorgetti, S

Eur. J. Biochem. 1994
7493944 The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis

Kalebic, T, Blakesley, V, LeRoith, D, Hernández-Sánchez, C, Helman, L

J. Biol. Chem. 1995
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane]

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