GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS

Stable Identifier
R-HSA-5686318
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
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SOS promotes the formation of GTP-bound RAS, thus activating this protein. RAS activation results in activation of the protein kinases RAF1, B-Raf, and MAP-ERK kinase kinase (MEKK), and the catalytic subunit of PI3K, as well as of a series of RALGEFs. The activation cycle of RAS GTPases is regulated by their interaction with specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). GEFs promote activation by inducing the release of GDP, whereas GAPs inactivate RAS-like proteins by stimulating their intrinsic GTPase activity.

Literature References
PubMed ID Title Journal Year
9690470 The structural basis of the activation of Ras by Sos

Boriack-Sjodin, PA, Margarit, SM, Bar-Sagi, D, Kuriyan, J

Nature 1998
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Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-3Y-SHC1 [cytosol]
Physical Entity
GRB2-1:SOS1:p-3Y-SHC1 [cytosol]
Activity
Ras guanyl-nucleotide exchange factor activity (0005088)
Inferred From
SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)
Created
Jupe, S  (2015-04-01)