IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1

Stable Identifier
R-HSA-2404195
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SHC binds the NPEY-juxtamembrane motif of the phosphorylated insulin-like growth factor receptor (IGF1R) (Giorgetti et al. 1994, Tartare-Deckert et al. 1995).

Literature References
PubMed ID Title Journal Year
7559507 Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system

Murdaca, J, Sawka-Verhelle, D, Tartare-Deckert, S, Van Obberghen, E

J. Biol. Chem. 1995
8033892 Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

Pelicci, G, Pelicci, PG, Van Obberghen, E, Giorgetti, S

Eur. J. Biochem. 1994
Participants
Input
Output
Participates
as an event of
Orthologous Events
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Canis familiaris)
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Danio rerio)
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Gallus gallus)
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Mus musculus)
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Rattus norvegicus)
Authored
May, B  (2012-07-07)
Reviewed
Holzenberger, M  (2012-11-09)
Created
May, B  (2012-07-16)
Cite Us!