15k-LXA4 is reduced to dhk-LXA4 by PTGR1

Stable Identifier
R-HSA-2161844
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)
ReviewStatus
5/5
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15k-LXA4 is reduced to dhk-LXA4 by PTGR1
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Prostaglandin reductase 1 (PTGR1) aka LTB4DH, a 15-oxoprostaglandin 13-reductase (Yokomizo et al. 1996), metabolises 15-oxo lipoxin A4 aka 15-keto-LXA4 (15k-LXA4) to produce 13,14-dihydro-15-keto-Lipoxin A4 (dhk-LXA4). This reaction has been inferred from a reaction in pig (Clish et al. 2000).
Literature References
PubMed ID Title Journal Year
10837478 Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation

Clish, CB, Levy, BD, Chiang, N, Tai, HH, Serhan, CN

J Biol Chem 2000
8576264 cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase

Yokomizo, T, Ogawa, Y, Uozumi, N, Kume, K, Izumi, T, Shimizu, T

J Biol Chem 1996
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Output
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Catalyst Activity

13-lipoxin reductase activity of PTGR1 [cytosol]

Physical Entity
PTGR1 [cytosol] (Homo sapiens)
Activity
13-lipoxin reductase activity (GO:0036185)
Inferred From
15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Sus scrofa)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Hansen, TV  (2018-02-21)
Hill, DP  (2024-08-02)
Created
Williams, MG  (2012-03-14)
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