15k-LXA4 is reduced to dhk-LXA4 by PTGR1

Stable Identifier
R-HSA-2161844
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Prostaglandin reductase 1 (PTGR1) aka LTB4DH, a 15-oxoprostaglandin 13-reductase (Yokomizo et al. 1996), metabolises 15-oxo lipoxin A4 aka 15-keto-LXA4 (15k-LXA4) to produce 13,14-dihydro-15-keto-Lipoxin A4 (dhk-LXA4). This reaction has been inferred from a reaction in pig (Clish et al. 2000).

Literature References
PubMed ID Title Journal Year
8576264 cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase

Yokomizo, T, Ogawa, Y, Uozumi, N, Kume, K, Izumi, T, Shimizu, T

J Biol Chem 1996
10837478 Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation

Clish, CB, Levy, BD, Chiang, N, Tai, HH, Serhan, CN

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
13-lipoxin reductase activity of PTGR1 [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
Cite Us!