15k-LXA4 is reduced to dhk-LXA4 by PTGR1

Stable Identifier
R-SSC-2161847
Type
Reaction [transition]
Species
Sus scrofa
Compartment
General
SVG |   | PPTX  | SBGN
15k-LXA4 is reduced to dhk-LXA4 by PTGR1

In pigs, prostaglandin reductase 1 (PTGR1) aka LTB4DH, a 15-oxoprostaglandin 13-reductase, metabolises 15-oxo lipoxin A4 aka 15-keto-LXA4 (15k-LXA4) to produce 13,14-dihydro-15-keto-Lipoxin A4 (dhk-LXA4) (Clish et al. 2000).

Literature References
PubMed ID Title Journal Year
10837478 Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation

Clish, CB, Levy, BD, Chiang, N, Tai, HH, Serhan, CN

J Biol Chem 2000
Participants
Catalyst Activity
Catalyst Activity
Title
13-lipoxin reductase activity of PTGR1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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