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S1PR3 [plasma membrane]
Stable Identifier
R-HSA-419396
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sphingosine 1-phosphate receptor 3, S1PR3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
S1PR2-5 bind S1P (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
MMPs cleave HB-EGF (Homo sapiens)
S1P:S1PR3 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
S1P binds S1PR3 in response to E2 stimulation (Homo sapiens)
S1P:S1PR3 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
S1PR3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99500 S1PR3
Gene Names
S1PR3, C9orf108, C9orf47, EDG3
Chain
chain:1-378
Reference Genes
BioGPS Gene:1903 S1PR3
COSMIC (genes):C9orf47 S1PR3
COSMIC (genes):S1PR3 S1PR3
CTD Gene:1903 S1PR3
dbSNP Gene:1903 S1PR3
ENSEMBL:ENSG00000213694 S1PR3
HGNC:3167 S1PR3
KEGG:hsa:1903 S1PR3
Monarch:1903 S1PR3
NCBI Gene:1903 S1PR3
OMIM:601965 S1PR3
UCSC:Q99500 S1PR3
Reference Transcript
RefSeq:NM_005226.3 S1PR3
Other Identifiers
11725905_a_at
11725906_a_at
11737128_a_at
1564274_PM_at
1564274_at
17086621
1903
228176_PM_at
228176_at
231286_PM_at
231286_at
231741_PM_at
231741_at
3178549
3178550
3178551
3178552
3178553
3178554
3178555
3178556
3178557
3178558
3178559
3178560
3178561
3178562
3178563
46116_at
80110_at
8156278
83974_at
A_14_P125972
A_14_P132007
A_14_P135183
A_23_P112820
A_33_P3248638
A_33_P3281283
A_33_P3379061
GE558774
GE739172
GE80361
GE87306
GO:0003376
GO:0004930
GO:0005178
GO:0005515
GO:0005737
GO:0005886
GO:0006954
GO:0007186
GO:0007189
GO:0007193
GO:0007204
GO:0007219
GO:0008284
GO:0008289
GO:0009653
GO:0016020
GO:0019222
GO:0032651
GO:0038036
GO:0060089
GO:0098793
GO:1903141
HMNXSV003037185
HMNXSV003042654
Hs.160623.0.A1_3p_at
Hs.248107.0.S1_3p_at
Hs.55902.0.A1_3p_at
Hs2.353892.1.S1_3p_at
ILMN_1703531
ILMN_1794672
PH_hs_0017155
PH_hs_0030906
TC09002900.hg
TC09002901.hg
Participates
as an input of
S1P binds S1PR3 in response to E2 stimulation (Homo sapiens)
as a component of
S1P:S1PR3 [plasma membrane] (Homo sapiens)
as a member of
S1PR2-5 [plasma membrane] (Homo sapiens)
Inferred To
S1pr3 [plasma membrane]
(Mus musculus)
S1pr3 [plasma membrane]
(Rattus norvegicus)
s1pr3 [plasma membrane]
(Xenopus tropicalis)
S1PR3 [plasma membrane]
(Bos taurus)
S1PR3 [plasma membrane]
(Canis familiaris)
S1PR3 [plasma membrane]
(Gallus gallus)
S1PR3 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_005217.2
ZINC - World Drugs
S1PR3_HUMAN
Guide to Pharmacology - Targets
277
ENSEMBL
ENSP00000365006
,
ENST00000375846
,
ENST00000358157
,
ENSP00000350878
OpenTargets
ENSG00000213694
ZINC - FDA approved
S1PR3_HUMAN
ZINC - Substances
S1PR3_HUMAN
ZINC - Biogenic
S1PR3_HUMAN
ZINC target
Q99500
PRO
Q99500
GlyGen
Q99500
PDB
7EW3
,
7C4S
,
7EW2
,
7EW4
ZINC - Investigational
S1PR3_HUMAN
ZINC - Metabolites
S1PR3_HUMAN
HPA
ENSG00000213694-S1PR3
Pharos - Targets
Q99500
ZINC - Predictions - Purchasable
S1PR3_HUMAN
HMDB Protein
HMDBP10797
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06028 GYPB
1
GYPB [plasma membrane]
(R-HSA-8867209)
0.556
3
UniProt:P21964 COMT
2
COMT [cytosol]
(R-HSA-175974)
COMT [plasma membrane]
(R-HSA-379386)
0.556
3
UniProt:P16144 ITGB4
1
ITGB4 [plasma membrane]
(R-HSA-215947)
0.471
3
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