Catecholamine biosynthesis

Stable Identifier
R-HSA-209905
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Catecholamine biosynthesis
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The catecholamine neurotransmitters dopamine, noradrenaline and adrenaline are found in nervous tissue of animals. They are synthesized in catecholaminergic neurons by four enzymes from tyrosine to adrenaline: tyrosine hydroxylase (TH); aromatic L-amino acid decarboxylase (AADC); dopamine beta-hydroxylase (DBH); and phenylethanolamine N-methyltransferase (PNMT).
Literature References
PubMed ID Title Journal Year
363400 Catecholamines: role in health and disease

Laverty, R

Drugs 1978
1684650 Genes for human catecholamine-synthesizing enzymes

Nagatsu, T

Neurosci Res 1991
10691773 Catecholamine biosynthesis and physiological regulation in neuroendocrine cells

Flatmark, T

Acta Physiol Scand 2000
Participants
Events
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Event Information
Go Biological Process
catecholamine biosynthetic process (0042423)
Orthologous Events
Catecholamine biosynthesis (Bos taurus)
Catecholamine biosynthesis (Caenorhabditis elegans)
Catecholamine biosynthesis (Canis familiaris)
Catecholamine biosynthesis (Danio rerio)
Catecholamine biosynthesis (Dictyostelium discoideum)
Catecholamine biosynthesis (Drosophila melanogaster)
Catecholamine biosynthesis (Gallus gallus)
Catecholamine biosynthesis (Mus musculus)
Catecholamine biosynthesis (Rattus norvegicus)
Catecholamine biosynthesis (Sus scrofa)
Catecholamine biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-08)
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