Reactome | Dopamine is oxidised to noradrenaline

Dopamine is oxidised to noradrenaline

Stable Identifier

R-HSA-209891

Type

Reaction [transition]

Species

Homo sapiens

Compartment

secretory granule lumen

ReviewStatus

5/5

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Dopamine beta-hydroxylase (DBH; dopamine beta-monooxygenase) is a copper-containing glycoprotein consisting of four identical subunits and catalyzes the oxidation of dopamine to norepinephrine. It requires ascorbic acid as an electron donor. DBH is localized in the norepinephrinergic and epinephrinergic neurons in the central nervous system. The enzyme exists in the secretory vesicles as both soluble and membrane-bound forms. The soluble form is secreted with catecholamines by exocytosis whereas the membrane-bound form is recycled into the vesicles.

Literature References

PubMed ID	Title	Journal	Year
1857555	Expression of two forms of human dopamine-beta-hydroxylase in COS cells Kiuchi, K, Ishii, A, Kobayashi, K, Nagatsu, T	Neurosci Lett	1991
7961964	Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice Yamada, KM, Fujita, K, Sawada, H, Morita, S, Nagatsu, I, Kobayashi, K, Nagatsu, T, Mizuguchi, T	J Biol Chem	1994
3443096	The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme Mallet, J, Darmon, MC, Lamouroux, A, Henry, JP, Vigny, A, Franck, R, Faucon Biguet, N	EMBO J	1987