Dopamine is oxidised to noradrenaline

Stable Identifier
R-HSA-209891
Type
Reaction
Species
Homo sapiens
Compartment
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Dopamine beta-hydroxylase (DBH; dopamine beta-monooxygenase) is a copper-containing glycoprotein consisting of four identical subunits and catalyzes the oxidation of dopamine to norepinephrine. It requires ascorbic acid as an electron donor. DBH is localized in the norepinephrinergic and epinephrinergic neurons in the central nervous system. The enzyme exists in the secretory vesicles as both soluble and membrane-bound forms. The soluble form is secreted with catecholamines by exocytosis whereas the membrane-bound form is recycled into the vesicles.

Literature References
PubMed ID Title Journal Year
1857555 Expression of two forms of human dopamine-beta-hydroxylase in COS cells

Kiuchi, K, Ishii, A, Kobayashi, K, Nagatsu, T

Neurosci Lett 1991
7961964 Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice

Yamada, KM, Fujita, K, Sawada, H, Morita, S, Nagatsu, I, Kobayashi, K, Nagatsu, T, Mizuguchi, T

J Biol Chem 1994
3443096 The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme

Mallet, J, Darmon, MC, Lamouroux, A, Henry, JP, Vigny, A, Franck, R, Faucon Biguet, N

EMBO J 1987
Participants
Participates
Catalyst Activity

dopamine beta-monooxygenase activity of DBH tetramer [secretory granule lumen]

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