Dopamine is oxidised to noradrenaline

Stable Identifier
R-HSA-209891
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Dopamine beta-hydroxylase (DBH; dopamine beta-monooxygenase) is a copper-containing glycoprotein consisting of four identical subunits and catalyzes the oxidation of dopamine to norepinephrine. It requires ascorbic acid as an electron donor. DBH is localized in the norepinephrinergic and epinephrinergic neurons in the central nervous system. The enzyme exists in the secretory vesicles as both soluble and membrane-bound forms. The soluble form is secreted with catecholamines by exocytosis whereas the membrane-bound form is recycled into the vesicles.

Literature References
PubMed ID Title Journal Year
7961964 Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice

Kobayashi, K, Morita, S, Mizuguchi, T, Sawada, H, Yamada, KM, Nagatsu, I, Fujita, K, Nagatsu, T

J Biol Chem 1994
1857555 Expression of two forms of human dopamine-beta-hydroxylase in COS cells

Ishii, A, Kobayashi, K, Kiuchi, K, Nagatsu, T

Neurosci Lett 1991
3443096 The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme

Lamouroux, A, Vigny, A, Faucon Biguet, N, Darmon, MC, Franck, R, Henry, JP, Mallet, J

EMBO J 1987
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dopamine beta-monooxygenase activity of DBH tetramer [secretory granule lumen]
Physical Entity
Activity
Orthologous Events
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