Noradrenaline is converted to adrenaline

Stable Identifier
R-HSA-209903
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Noradrenaline is converted to adrenaline
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Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in catecholamine biosynthesis. It performs transmethylation of noradrenaline to adrenaline using S-adenosyl L-methionine (SAM) as the methyl donor.

Literature References
PubMed ID Title Journal Year
3372503 Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis

Nakazawa, A, Kishi, F, Ichinose, H, Fujita, K, Kobayashi, K, Oka, K, Nagatsu, T, Kaneda, N, Kurosawa, Y

J Biol Chem 1988
Participants
Input
Output
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as an event of
Catalyst Activity

phenylethanolamine N-methyltransferase activity of PNMT [cytosol]

Physical Entity
PNMT [cytosol] (Homo sapiens)
Activity
phenylethanolamine N-methyltransferase activity (GO:0004603)
Orthologous Events
Noradrenaline is converted to adrenaline (Bos taurus)
Noradrenaline is converted to adrenaline (Caenorhabditis elegans)
Noradrenaline is converted to adrenaline (Canis familiaris)
Noradrenaline is converted to adrenaline (Gallus gallus)
Noradrenaline is converted to adrenaline (Mus musculus)
Noradrenaline is converted to adrenaline (Rattus norvegicus)
Noradrenaline is converted to adrenaline (Sus scrofa)
Noradrenaline is converted to adrenaline (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-08)
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