Dopa is decarboxylated to dopamine

Stable Identifier
R-HSA-209924
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Dopa is decarboxylated to dopamine
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Aromatic L-amino acid decarboxylase (AADC, dopa decarboxylase) decarboxylates dopa to form dopamine.

Literature References
PubMed ID Title Journal Year
1540578 Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis

Hori, T, Ichinose, H, Takahashi, E, Sumi-Ichinose, C, Nagatsu, T

Biochemistry 1992
2590185 Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase

Titani, K, Ichinose, H, Fujita, K, Nagatsu, T, Kurosawa, Y

Biochem Biophys Res Commun 1989
Participants
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Output
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as an event of
Catalyst Activity

aromatic-L-amino-acid decarboxylase activity of DDC dimer [cytosol]

Physical Entity
DDC dimer [cytosol] (Homo sapiens)
Activity
aromatic-L-amino-acid decarboxylase activity (GO:0004058)
Orthologous Events
Dopa is decarboxylated to dopamine (Bos taurus)
Dopa is decarboxylated to dopamine (Caenorhabditis elegans)
Dopa is decarboxylated to dopamine (Canis familiaris)
Dopa is decarboxylated to dopamine (Danio rerio)
Dopa is decarboxylated to dopamine (Drosophila melanogaster)
Dopa is decarboxylated to dopamine (Gallus gallus)
Dopa is decarboxylated to dopamine (Mus musculus)
Dopa is decarboxylated to dopamine (Rattus norvegicus)
Dopa is decarboxylated to dopamine (Sus scrofa)
Dopa is decarboxylated to dopamine (Xenopus tropicalis)
Cross References
Rhea
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-08)
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