Tyrosine is hydroxylated to dopa

Stable Identifier
R-HSA-209823
Type
Reaction
Species
Homo sapiens
Compartment
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Tyrosine hydroxylase (TH) is the first enzyme in catecholamine biosynthesis, as well as being the rate-limiting enzyme in that process. TH requires tetrahydrobiopterin and uses iron as a cofactor in the 3,4-hydroxylation of tyrosine to produce dopa. Four isoforms of TH are expressed in the human brain and all have enzymatic activity (Nagatsu, T, 1989; Lewis, DA et al, 1993).

Literature References
PubMed ID Title Journal Year
8101641 Four isoforms of tyrosine hydroxylase are expressed in human brain

Lewis, DA, Haycock, JW, Melchitzky, DS

Neuroscience 1993
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Participates
Catalyst Activity

tyrosine 3-monooxygenase activity of TH:Fe2+ [cytosol]

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