Tyrosine is hydroxylated to dopa

Stable Identifier
R-HSA-209823
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Tyrosine hydroxylase (TH) is the first enzyme in catecholamine biosynthesis, as well as being the rate-limiting enzyme in that process. TH requires tetrahydrobiopterin and uses iron as a cofactor in the 3,4-hydroxylation of tyrosine to produce dopa. Four isoforms of TH are expressed in the human brain and all have enzymatic activity (Nagatsu, T, 1989; Lewis, DA et al, 1993).

Literature References
PubMed ID Title Journal Year
8101641 Four isoforms of tyrosine hydroxylase are expressed in human brain

Lewis, DA, Melchitzky, DS, Haycock, JW

Neuroscience 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
tyrosine 3-monooxygenase activity of TH:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
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