Tyrosine is hydroxylated to dopa

Stable Identifier
R-HSA-209823
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Tyrosine hydroxylase (TH) is the first enzyme in catecholamine biosynthesis, as well as being the rate-limiting enzyme in that process. TH requires tetrahydrobiopterin and uses iron as a cofactor in the 3,4-hydroxylation of tyrosine to produce dopa. Four isoforms of TH are expressed in the human brain and all have enzymatic activity (Nagatsu, T, 1989; Lewis, DA et al, 1993).
Literature References
PubMed ID Title Journal Year
8101641 Four isoforms of tyrosine hydroxylase are expressed in human brain

Lewis, DA, Haycock, JW, Melchitzky, DS

Neuroscience 1993
Participants
Participates
Catalyst Activity

tyrosine 3-monooxygenase activity of TH:Fe2+ [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!