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NF-kB is activated and signals survival
Stable Identifier
R-HSA-209560
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
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Upon activation in response to NGF, NF-kB moves to the nucleus, where it turns on genes that promote survival, and triggers the expression of HES1/5 to modulate dendritic growth.
Literature References
PubMed ID
Title
Journal
Year
16187223
NF-kappaB in the survival and plasticity of neurons
Mattson, MP
Neurochem Res
2005
Participants
Events
IKKbeta is activated
(Homo sapiens)
IKKbeta phosphorylates IkB causing NF-kB to dissociate
(Homo sapiens)
IkB is ubiquitinated and degraded
(Homo sapiens)
NF-kB migrates to the nucleus and turns on transcription
(Homo sapiens)
Participates
as an event of
p75NTR signals via NF-kB (Homo sapiens)
Orthologous Events
NF-kB is activated and signals survival (Bos taurus)
NF-kB is activated and signals survival (Canis familiaris)
NF-kB is activated and signals survival (Danio rerio)
NF-kB is activated and signals survival (Drosophila melanogaster)
NF-kB is activated and signals survival (Gallus gallus)
NF-kB is activated and signals survival (Mus musculus)
NF-kB is activated and signals survival (Rattus norvegicus)
NF-kB is activated and signals survival (Sus scrofa)
NF-kB is activated and signals survival (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000883
,
BIOMD0000000407
,
BIOMD0000000243
,
BIOMD0000000477
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-12-19)
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