Atypical PKC isoforms phosphorylate the beta subunit of the IKK complex (on Serines 177 and 181) thereby serving as an IKK kinase. TRAF6 and p62 as well appear to have a role in IKK activation. TRAF6 mediates the assembly of K63-linked poly-Ub chains required for IKK activation. The ubiquitin binding property of p62 may also be relevant in regulating IKK activation.
Bren, G, Moscat, J, Diaz-Meco, MT, Paya, CV, Lallena, MJ
protein kinase C activity of NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane]
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