IKKbeta is activated

Stable Identifier
R-HSA-193703
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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IKKbeta is activated
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Atypical PKC isoforms phosphorylate the beta subunit of the IKK complex (on Serines 177 and 181) thereby serving as an IKK kinase. TRAF6 and p62 as well appear to have a role in IKK activation. TRAF6 mediates the assembly of K63-linked poly-Ub chains required for IKK activation. The ubiquitin binding property of p62 may also be relevant in regulating IKK activation.
Literature References
PubMed ID Title Journal Year
10022904 Activation of IkappaB kinase beta by protein kinase C isoforms

Bren, G, Moscat, J, Diaz-Meco, MT, Paya, CV, Lallena, MJ

Mol Cell Biol 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

diacylglycerol-dependent serine/threonine kinase activity of NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane]

Physical Entity
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
Activity
diacylglycerol-dependent serine/threonine kinase activity (GO:0004697)
Orthologous Events
IKKbeta is activated (Bos taurus)
IKKbeta is activated (Canis familiaris)
IKKbeta is activated (Gallus gallus)
IKKbeta is activated (Mus musculus)
IKKbeta is activated (Rattus norvegicus)
IKKbeta is activated (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
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