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Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
Stable Identifier
R-HSA-203494
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Activation of ZAP-70 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
Participants
components
CD4 [plasma membrane]
(Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane]
(Homo sapiens)
p-Y394-LCK [cytosol]
(Homo sapiens)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane]
(Homo sapiens)
Participates
as an input of
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
as an output of
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
as a component of
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Inferred To
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Sus scrofa)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Xenopus tropicalis)
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