Phosphorylation of ITAM motifs in CD3 complexes

Stable Identifier
R-HSA-202165
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The autophosphorylated, active Lck is now proximally positioned to phosphorylate specific tyrosine residues within ITAMs (immunoreceptor tyrosine-based activation motifs) located within the CD3 and the TCR zeta signaling chains of the TCR. ITAMs consist of evolutionarily conserved amino-acid sequence motifs of D/ExYxxLx(6-8)YxxL. Both the tyrosine residues in the motif are phosphorylated by Lck and the TCR complex include 10 ITAMs with one ITAM in each of the CD3 chains including the three tandem ITAMs in each zeta chains.

Literature References
PubMed ID Title Journal Year
16364187 T-cell signalling and immune system disorders

Wilkinson, B, Downey, JS, Rudd, CE

Expert Rev Mol Med 2005
15084594 T cell receptor signaling: beyond complex complexes

Huang, Y, Wange, RL

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created