Phosphorylation of ITAM motifs in CD3 complexes

Stable Identifier
R-HSA-202165
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Phosphorylation of ITAM motifs in CD3 complexes
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The autophosphorylated, active Lck is now proximally positioned to phosphorylate specific tyrosine residues within ITAMs (immunoreceptor tyrosine-based activation motifs) located within the CD3 and the TCR zeta signaling chains of the TCR. ITAMs consist of evolutionarily conserved amino-acid sequence motifs of D/ExYxxLx(6-8)YxxL. Both the tyrosine residues in the motif are phosphorylated by Lck and the TCR complex include 10 ITAMs with one ITAM in each of the CD3 chains including the three tandem ITAMs in each zeta chains.
Literature References
PubMed ID Title Journal Year
15084594 T cell receptor signaling: beyond complex complexes

Huang, Y, Wange, RL

J Biol Chem 2004
16364187 T-cell signalling and immune system disorders

Downey, JS, Rudd, CE, Wilkinson, B

Expert Rev Mol Med 2005
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Output
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Catalyst Activity

protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]

Physical Entity
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)
Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)
Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)
Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)
Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)
Authored
Garapati, P V  (2008-01-24)
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)
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