Reactome | Phosphorylation of ITAM motifs in CD3 complexes

Phosphorylation of ITAM motifs in CD3 complexes

Stable Identifier

R-HSA-202165

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Phosphorylation of ITAM motifs in CD3 complexes

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The autophosphorylated, active Lck is now proximally positioned to phosphorylate specific tyrosine residues within ITAMs (immunoreceptor tyrosine-based activation motifs) located within the CD3 and the TCR zeta signaling chains of the TCR. ITAMs consist of evolutionarily conserved amino-acid sequence motifs of D/ExYxxLx(6-8)YxxL. Both the tyrosine residues in the motif are phosphorylated by Lck and the TCR complex include 10 ITAMs with one ITAM in each of the CD3 chains including the three tandem ITAMs in each zeta chains.

Literature References

PubMed ID	Title	Journal	Year
16364187	T-cell signalling and immune system disorders Wilkinson, B, Downey, JS, Rudd, CE	Expert Rev Mol Med	2005
15084594	T cell receptor signaling: beyond complex complexes Huang, Y, Wange, RL	J Biol Chem	2004