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p-14S-NFATC2 [cytosol]
Stable Identifier
R-HSA-2025848
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
14P-NFATC2, Nuclear factor of activated T-cells, cytoplasmic 2, NFAC2_HUMAN, NFATC2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
Calcineurin binds NFATC1,2,3 (Homo sapiens)
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
p-NFATC1,2,3 [cytosol] (Homo sapiens)
p-14S-NFATC2 [cytosol] (Homo sapiens)
p-NFATC1,2,3 [cytosol] (Homo sapiens)
p-14S-NFATC2 [cytosol] (Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
p-NFATC1,2,3 [cytosol] (Homo sapiens)
p-14S-NFATC2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
p-NFATC1,2,3 [cytosol] (Homo sapiens)
p-14S-NFATC2 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
p-NFATC1,2,3 [cytosol] (Homo sapiens)
p-14S-NFATC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13469 NFATC2
Gene Names
NFATC2, NFAT1, NFATP
Chain
chain:1-925
Reference Genes
BioGPS Gene:4773 NFATC2
COSMIC (genes):NFATC2 NFATC2
CTD Gene:4773 NFATC2
dbSNP Gene:4773 NFATC2
ENSEMBL:ENSG00000101096.20 NFATC2
HGNC:7776 NFATC2
KEGG Gene (Homo sapiens):4773 NFATC2
Monarch:4773 NFATC2
NCBI Gene:4773 NFATC2
OMIM:600490 NFATC2
UCSC:Q13469 NFATC2
Reference Transcript
RefSeq:NM_173091.3 NFATC2
RefSeq:NM_001136021.2 NFATC2
RefSeq:NM_001258294.1 NFATC2
RefSeq:NM_001258292.1 NFATC2
RefSeq:NM_012340.4 NFATC2
RefSeq:NM_001258296.1 NFATC2
Other Identifiers
11738814_a_at
11762151_a_at
11763307_s_at
16920315
224542_PM_s_at
224542_s_at
226991_PM_at
226991_at
228442_PM_at
228442_at
231801_PM_at
231801_at
3909546
3909548
3909550
3909552
3909554
3909555
3909556
3909557
3909558
3909563
3909564
3909582
3909583
3909584
3909585
3909586
3909607
3909612
3909614
3909628
3909631
3909635
3909636
3909637
3909646
3909765
3909767
4773
48029_at
56993_at
8067040
A_23_P91278
A_24_P525917
A_33_P3215333
GE483533
GE88549
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006974
GO:0009410
GO:0010628
GO:0014904
GO:0016477
GO:0019902
GO:0023052
GO:0030154
GO:0030890
GO:0033173
GO:0035976
GO:0043226
GO:0043565
GO:0045893
GO:0045944
GO:0048856
GO:0048870
GO:0050853
GO:0060090
GO:0071889
GO:0098781
GO:0140110
GO:1901741
GO:1905064
GO:1990837
GO:1990904
HMNXSV003033553
Hs.102248.0.S1_3p_at
Hs.112157.0.A1_3p_at
Hs.248037.1.S2_3p_at
ILMN_1661083
ILMN_1675461
PH_hs_0023999
TC20000942.hg
g1353775_3p_a_at
Participates
as a member of
p-NFATC1,2,3 [cytosol] (Homo sapiens)
Other forms of this molecule
NFATC2 [nucleoplasm]
p-S243-NFATC2 [cytosol]
p-S243-NFATC2 [nucleoplasm]
Inferred From
14P-Nfatc2 [cytosol]
(Mus musculus)
Inferred To
phospho-nfatc2 [cytosol]
(Xenopus tropicalis)
phospho-p-14S-NFATC2 [cytosol]
(Canis familiaris)
phospho-p-14S-NFATC2 [cytosol]
(Danio rerio)
phospho-NFATC2 [cytosol]
(Bos taurus)
phospho-NFATC2 [cytosol]
(Gallus gallus)
phospho-NFATC2 [cytosol]
(Sus scrofa)
phospho-NFAT [cytosol]
(Drosophila melanogaster)
phospho-Nfatc2 [cytosol]
(Mus musculus)
phospho-Nfatc2 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 171
Coordinate
171
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 172
Coordinate
172
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 174
Coordinate
174
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 175
Coordinate
175
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 177
Coordinate
177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 213
Coordinate
213
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 217
Coordinate
217
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 221
Coordinate
221
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 268
Coordinate
268
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 274
Coordinate
274
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 276
Coordinate
276
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 280
Coordinate
280
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 326
Coordinate
326
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 243
Coordinate
243
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001245223.1
,
NP_001129493.1
,
NP_775114.1
,
NP_001245221.1
,
NP_036472.2
,
NP_001245225.1
OpenTargets
ENSG00000101096
GeneCards
Q13469
HPA
ENSG00000101096-NFATC2
Ensembl
ENSP00000396471
,
ENSP00000360619
,
ENST00000396009
,
ENSP00000477370
,
ENST00000609943
,
ENSP00000379330
,
ENST00000610033
,
ENST00000371564
,
ENST00000414705
,
ENST00000609507
,
ENSP00000477342
,
ENSG00000101096
,
ENSP00000477142
PRO
Q13469
Pharos - Targets
Q13469
HMDB Protein
HMDBP01678
PDB
1P7H
,
2O93
,
1A02
,
1OWR
,
1S9K
,
2AS5
,
3QRF
,
1PZU
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86Y07-1 VRK2
0.611
3
UniProt:Q86Y07-2 VRK2
2
VRK2-2 [cytosol]
(R-HSA-2995378)
VRK2-2 [nucleoplasm]
(R-HSA-2993893)
0.611
4
IntAct:EBI-983681 ARRE2
0.591
5
UniProt:Q08209-1 PPP3CA
0.558
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.558
3
UniProt:IL2 ENSG00000109471
0.527
2
IntAct:EBI-10021565 CCL5-DERIVED
0.499
2
UniProt:P16220 CREB1
2
p-S119-CREB1 [nucleoplasm]
(R-HSA-111910)
CREB1 [nucleoplasm]
(R-HSA-52777)
0.499
2
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