Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-Y611-PRLR [endosome lumen]
Stable Identifier
R-HSA-2002376
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome lumen
Synonyms
p(S349)-PRLR, Prolactin receptor, PRLR_HUMAN, PRLR
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
Prolactin receptor is internalized (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
p-S349-PRLR:JAK2 [endosome lumen] (Homo sapiens)
p-Y611-PRLR [endosome lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16471 PRLR
Gene Names
PRLR
Chain
signal peptide:1-24, chain:25-622
Reference Genes
COSMIC (genes):PRLR PRLR
dbSNP Gene:5618 PRLR
ENSEMBL:ENSG00000113494 PRLR
Participates
as a component of
p-S349-PRLR:JAK2 [endosome lumen] (Homo sapiens)
Other forms of this molecule
PRLR [plasma membrane]
p-Y611-PRLR [plasma membrane]
Inferred To
phospho-prlr [endosome lumen]
(Xenopus tropicalis)
phospho-p-Y611-PRLR [endosome lumen]
(Mus musculus)
phospho-p-Y611-PRLR [endosome lumen]
(Rattus norvegicus)
phospho-p-Y611-PRLR [endosome lumen]
(Sus scrofa)
phospho-PRLR [endosome lumen]
(Canis familiaris)
phospho-PRLR [endosome lumen]
(Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 611
Coordinate
611
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IY26 PLPP6
1
PLPP6 [plasma membrane]
(R-HSA-8952144)
0.556
3
UniProt:Q9Y5U4 INSIG2
1
INSIG2 [endoplasmic reticulum membrane]
(R-HSA-1655736)
0.556
3
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text