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PRLR [plasma membrane]
Stable Identifier
R-HSA-976964
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Prolactin receptor, PRLR_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
JAK2 phosphorylation (Homo sapiens)
Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
JAK2 phosphorylation (Homo sapiens)
Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR activation (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR associates with JAK2 (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR is phosphorylated at Ser-349 (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR:JAK2 dimerizes (Homo sapiens)
PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
SH2B binds JAK2 (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
Tyrosine phosphorylation of PRLR (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
Activated PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
PRLR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16471 PRLR
Gene Names
PRLR
Chain
signal peptide:1-24, chain:25-622
Reference Genes
BioGPS Gene:5618 PRLR
COSMIC - genes:PRLR PRLR
CTD Gene:5618 PRLR
dbSNP Gene:5618 PRLR
ENSEMBL:ENSG00000113494 PRLR
HGNC:9446 PRLR
KEGG:hsa:5618 PRLR
Monarch:5618 PRLR
NCBI Gene:5618 PRLR
OMIM:176761 PRLR
UCSC:P16471 PRLR
Reference Transcript
RefSeq:NM_001204314.2 PRLR
RefSeq:XM_006714484.3 PRLR
RefSeq:XM_054352940.1 PRLR
RefSeq:NM_001204316.1 PRLR
RefSeq:XM_047417390.1 PRLR
RefSeq:XM_047417388.1 PRLR
RefSeq:NM_001204318.1 PRLR
RefSeq:XM_054352939.1 PRLR
RefSeq:XM_011514068.3 PRLR
RefSeq:NM_000949.7 PRLR
RefSeq:NM_001204315.1 PRLR
RefSeq:NM_001204317.1 PRLR
RefSeq:XM_054352938.1 PRLR
Participates
as an input of
PRLR associates with JAK2 (Homo sapiens)
as a component of
PRLR:JAK2 [plasma membrane] (Homo sapiens)
Activated PRLR:JAK2 [plasma membrane] (Homo sapiens)
Activated PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y611-PRLR [plasma membrane]
p-Y611-PRLR [endosome lumen]
Inferred To
Homologues of PRLR [plasma membrane]
(Sus scrofa)
prlra [plasma membrane]
(Danio rerio)
PRLR [plasma membrane]
(Bos taurus)
PRLR [plasma membrane]
(Canis familiaris)
PRLR [plasma membrane]
(Gallus gallus)
PRLR [plasma membrane]
(Mus musculus)
PRLR [plasma membrane]
(Rattus norvegicus)
PRLR [plasma membrane]
(Sus scrofa)
prlr [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001191247.1
,
NP_001191246.1
,
XP_047273344.1
,
NP_001191245.1
,
NP_001191244.1
,
XP_006714547.1
,
XP_054208914.1
,
XP_054208915.1
,
XP_011512370.1
,
XP_054208913.1
,
XP_047273346.1
,
NP_000940.1
,
NP_001191243.1
Guide to Pharmacology - Targets
1721
OpenTargets
ENSG00000113494
ENSEMBL
ENSP00000311613
,
ENST00000513753
,
ENST00000348262
,
ENSP00000422935
,
ENST00000514088
,
ENST00000511486
,
ENST00000619676
,
ENST00000618457
,
ENST00000310101
,
ENST00000542609
,
ENSP00000309008
,
ENSG00000113494
,
ENSP00000424841
,
ENSP00000482689
,
ENSP00000484768
,
ENST00000509140
,
ENSP00000231423
,
ENSP00000425300
,
ENSP00000441813
,
ENSP00000482954
,
ENST00000231423
,
ENST00000620785
,
ENSP00000422556
ZINC - Substances
PRLR_HUMAN
ZINC target
P16471
PRO
P16471
GlyGen
P16471
PDB
3D48
,
4I18
,
3NCE
,
3MZG
,
3NCF
,
3NCB
,
3N06
,
2N7I
,
2LFG
,
1BP3
,
3N0P
,
3NCC
HPA
ENSG00000113494-PRLR
GeneCards
PRLR
Pharos - Targets
P16471
Orphanet
PRLR
ZINC - Predictions - Purchasable
PRLR_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IY26 PLPP6
1
PLPP6 [plasma membrane]
(R-HSA-8952144)
0.556
3
UniProt:Q9Y5U4 INSIG2
1
INSIG2 [endoplasmic reticulum membrane]
(R-HSA-1655736)
0.556
3
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