Reactome | p-Y611-PRLR [plasma membrane]

p-Y611-PRLR [plasma membrane]

Stable Identifier

R-HSA-1369104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p(Y611)-PRLR, Prolactin receptor, PRLR_HUMAN, PRLR

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Prolactin receptor signaling (Homo sapiens)
    - PRLR binds SCF beta-TrCP complex (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - PRLR binds SHP2 (PTPN11) (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - PRLR binds STAT5 (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - PRLR is phosphorylated at Ser-349 (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - PRLR-bound STAT5 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - Prolactin receptor is internalized (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - SHP2 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - Tyrosine phosphorylation of PRLR (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16471 PRLR

Gene Names

PRLR

Chain

signal peptide:1-24, chain:25-622

Reference Genes

BioGPS Gene:5618 PRLR

COSMIC (genes):PRLR PRLR

CTD Gene:5618 PRLR

dbSNP Gene:5618 PRLR

ENSEMBL:ENSG00000113494 PRLR

HGNC:9446 PRLR

KEGG:hsa:5618 PRLR

Monarch:5618 PRLR

NCBI Gene:5618 PRLR

OMIM:176761 PRLR

UCSC:P16471 PRLR

Reference Transcript

Participates

as a component of

Other forms of this molecule

PRLR [plasma membrane]

p-Y611-PRLR [endosome lumen]

Inferred To

phospho-Prlr [plasma membrane] (Mus musculus)

phospho-Prlr [plasma membrane] (Rattus norvegicus)

phospho-prlr [plasma membrane] (Xenopus tropicalis)

phospho-prlra [plasma membrane] (Danio rerio)

phospho-PRLR [plasma membrane] (Bos taurus)

phospho-PRLR [plasma membrane] (Canis familiaris)

phospho-PRLR [plasma membrane] (Gallus gallus)

phospho-PRLR [plasma membrane] (Sus scrofa)

Homologues of p-Y611-PRLR [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 611

Coordinate

611

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_047273346.1, XP_016865135.1, NP_001191243.1, XP_054208915.1, XP_054208914.1, XP_011512371.1, XP_054208913.1, XP_011512370.1, XP_047273344.1, XP_006714547.1, NP_001191245.1, NP_001191244.1, NP_000940.1, NP_001191246.1, NP_001191247.1

Guide to Pharmacology - Targets

1721

OpenTargets

ENSG00000113494

ENSEMBL

ENSP00000309008, ENST00000310101, ENSP00000311613, ENST00000231423, ENSP00000441813, ENSP00000482954, ENST00000348262, ENSP00000424841, ENST00000513753, ENSG00000113494, ENST00000514088, ENST00000511486, ENSP00000425300, ENSP00000231423, ENSP00000422556, ENST00000509140, ENST00000542609, ENSP00000482689, ENSP00000484768, ENSP00000422935, ENST00000620785, ENST00000618457, ENST00000619676

ZINC - Substances

PRLR_HUMAN

ZINC target

P16471

PRO

P16471

GlyGen

P16471

PDB

3MZG, 3NCE, 4I18, 3D48, 3NCC, 3N0P, 3NCB, 3N06, 1BP3, 2N7I, 3NCF, 2LFG

HPA

ENSG00000113494-PRLR

GeneCards

PRLR

Pharos - Targets

P16471

Orphanet

PRLR

ZINC - Predictions - Purchasable

PRLR_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:Q9Y5U4 INSIG2	1	INSIG2 [endoplasmic reticulum membrane] (R-HSA-1655736)	0.556	3