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p-Y611-PRLR [plasma membrane]
Stable Identifier
R-HSA-1369104
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p(Y611)-PRLR, Prolactin receptor, PRLR_HUMAN, PRLR
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
PRLR binds SCF beta-TrCP complex (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR binds SHP2 (PTPN11) (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR binds STAT5 (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR is phosphorylated at Ser-349 (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR-bound STAT5 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
Prolactin receptor is internalized (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
SHP2 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
Tyrosine phosphorylation of PRLR (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16471 PRLR
Gene Names
PRLR
Chain
signal peptide:1-24, chain:25-622
Reference Genes
BioGPS Gene:5618 PRLR
COSMIC (genes):PRLR PRLR
CTD Gene:5618 PRLR
dbSNP Gene:5618 PRLR
ENSEMBL:ENSG00000113494 PRLR
HGNC:9446 PRLR
KEGG:hsa:5618 PRLR
Monarch:5618 PRLR
NCBI Gene:5618 PRLR
OMIM:176761 PRLR
UCSC:P16471 PRLR
Reference Transcript
RefSeq:NM_000949.6 PRLR
RefSeq:NM_001204314.2 PRLR
RefSeq:NM_001204315.1 PRLR
RefSeq:XM_011514068.2 PRLR
RefSeq:XM_006714484.2 PRLR
RefSeq:NM_001204316.1 PRLR
RefSeq:NM_001204317.1 PRLR
RefSeq:XM_011514069.2 PRLR
RefSeq:XM_017009646.1 PRLR
RefSeq:NM_001204318.1 PRLR
Other Identifiers
1078_at
1079_g_at
11723501_at
11723502_at
11723503_at
11753026_a_at
11760771_a_at
16995177
206346_PM_at
206346_at
210476_PM_s_at
210476_s_at
211917_PM_s_at
211917_s_at
216638_PM_s_at
216638_s_at
227629_PM_at
227629_at
231981_PM_at
231981_at
243755_PM_at
243755_at
2853099
2853100
2853101
2853103
2853104
2853105
2853106
2853107
2853108
2853109
2853110
2853111
2853112
2853113
2853114
2853115
2853116
2853117
2853118
2853119
2853120
2853121
2853122
2853123
2853124
2853125
2853130
2853131
2853132
2853133
2853135
2853136
2853137
2853138
2853139
2853148
2853153
2853154
2853167
2853168
2853181
2853182
2853183
42824_at
43933_at
5618
56729_at
75460_at
8111490
81772_at
82529_r_at
A_23_P167468
A_24_P40737
A_24_P671164
A_33_P3416757
GE55950
GE57926
GE701898
GO:0004896
GO:0004925
GO:0005515
GO:0005576
GO:0005886
GO:0006629
GO:0006694
GO:0007171
GO:0007259
GO:0007566
GO:0007595
GO:0008284
GO:0008289
GO:0009617
GO:0009897
GO:0009986
GO:0016020
GO:0017046
GO:0019221
GO:0019901
GO:0019955
GO:0022414
GO:0030154
GO:0030155
GO:0030856
GO:0030890
GO:0031904
GO:0032870
GO:0038161
GO:0042976
GO:0043066
GO:0043235
GO:0046872
GO:0048856
GO:0060089
GO:0060644
GO:0060736
GO:0060749
GO:0061180
GO:0065003
GO:0097011
GO:0120162
HMNXSV003029258
HMNXSV003039519
HMNXSV003056739
Hs.166658.0.A1_3p_at
Hs.166658.0.A1_3p_x_at
Hs.1906.2.S1_3p_s_at
Hs.25252.0.S1_3p_at
Hs.35156.0.S1_3p_at
ILMN_1669781
ILMN_2175236
M31661_at
PH_hs_0023090
PH_hs_0041165
TC05001261.hg
TC05002950.hg
g13605397_3p_s_at
g4506106_3p_at
Participates
as a component of
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PRLR [plasma membrane]
p-Y611-PRLR [endosome lumen]
Inferred To
phospho-p-Y611-PRLR [plasma membrane]
(Mus musculus)
phospho-p-Y611-PRLR [plasma membrane]
(Rattus norvegicus)
phospho-p-Y611-PRLR [plasma membrane]
(Sus scrofa)
phospho-prlr [plasma membrane]
(Xenopus tropicalis)
phospho-PRLR [plasma membrane]
(Canis familiaris)
phospho-PRLR [plasma membrane]
(Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 611
Coordinate
611
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000940.1
,
NP_001191246.1
,
NP_001191247.1
,
XP_006714547.1
,
NP_001191245.1
,
NP_001191244.1
,
XP_016865135.1
,
XP_011512370.1
,
XP_011512371.1
,
NP_001191243.1
Guide to Pharmacology - Targets
1721
OpenTargets
ENSG00000113494
ENSEMBL
ENST00000620785
,
ENSP00000311613
,
ENST00000618457
,
ENST00000511486
,
ENST00000619676
,
ENSP00000422556
,
ENST00000231423
,
ENSP00000441813
,
ENST00000509140
,
ENSP00000231423
,
ENSP00000422935
,
ENST00000348262
,
ENSP00000424841
,
ENSP00000484768
,
ENSP00000482689
,
ENSP00000425300
,
ENSP00000482954
,
ENSP00000309008
,
ENST00000513753
,
ENST00000514088
,
ENST00000542609
,
ENST00000310101
ZINC - Substances
PRLR_HUMAN
ZINC target
P16471
PRO
P16471
GlyGen
P16471
PDB
3NCB
,
3N06
,
3N0P
,
3D48
,
3NCC
,
3MZG
,
4I18
,
3NCE
,
2N7I
,
2LFG
,
1BP3
,
3NCF
HPA
ENSG00000113494-PRLR
Pharos - Targets
P16471
Orphanet
PRLR
ZINC - Predictions - Purchasable
PRLR_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5U4 INSIG2
1
INSIG2 [endoplasmic reticulum membrane]
(R-HSA-1655736)
0.556
3
UniProt:Q8IY26 PLPP6
1
PLPP6 [plasma membrane]
(R-HSA-8952144)
0.556
3
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