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p-Y611-PRLR [plasma membrane]
Stable Identifier
R-HSA-1369104
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p(Y611)-PRLR, Prolactin receptor, PRLR_HUMAN, PRLR
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
PRLR binds SCF beta-TrCP complex (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR binds SHP2 (PTPN11) (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR binds STAT5 (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR is phosphorylated at Ser-349 (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR-bound STAT5 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
Prolactin receptor is internalized (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
SHP2 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
Tyrosine phosphorylation of PRLR (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
p-Y611-PRLR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16471 PRLR
Gene Names
PRLR
Chain
signal peptide:1-24, chain:25-622
Reference Genes
BioGPS Gene:5618 PRLR
COSMIC (genes):PRLR PRLR
CTD Gene:5618 PRLR
dbSNP Gene:5618 PRLR
ENSEMBL:ENSG00000113494 PRLR
HGNC:9446 PRLR
KEGG Gene (Homo sapiens):5618 PRLR
Monarch:5618 PRLR
NCBI Gene:5618 PRLR
OMIM:176761 PRLR
UCSC:P16471 PRLR
Reference Transcript
RefSeq:NM_000949.6 PRLR
RefSeq:NM_001204318.1 PRLR
RefSeq:XM_006714484.2 PRLR
RefSeq:NM_001204315.1 PRLR
RefSeq:XM_011514068.2 PRLR
RefSeq:NM_001204314.2 PRLR
RefSeq:NM_001204316.1 PRLR
RefSeq:XM_011514069.2 PRLR
RefSeq:NM_001204317.1 PRLR
RefSeq:XM_017009646.1 PRLR
Other Identifiers
0006860048
0104280132
1078_at
1079_g_at
11723501_at
11723502_at
11723503_at
11753026_a_at
11760771_a_at
16995177
206346_at
210476_s_at
211917_s_at
216638_s_at
227629_at
231981_at
243755_at
2853099
2853100
2853101
2853103
2853104
2853105
2853106
2853107
2853108
2853109
2853110
2853111
2853112
2853113
2853114
2853115
2853116
2853117
2853118
2853119
2853120
2853121
2853122
2853123
2853124
2853125
2853133
2853135
2853136
2853137
2853138
2853139
2853148
2853167
2853168
42824_at
43933_at
5618
56729_at
75460_at
8111490
81772_at
82529_r_at
A_23_P167468
A_24_P40737
A_24_P671164
A_33_P3416757
GE55950
GE57926
GE701898
GO:0000003
GO:0003674
GO:0004896
GO:0004923
GO:0004924
GO:0004925
GO:0005127
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005737
GO:0005768
GO:0005886
GO:0006464
GO:0006629
GO:0006694
GO:0006810
GO:0007165
GO:0007171
GO:0007566
GO:0007595
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009058
GO:0009897
GO:0009986
GO:0016020
GO:0016021
GO:0017046
GO:0019221
GO:0019955
GO:0022607
GO:0031410
GO:0031904
GO:0032991
GO:0038161
GO:0038165
GO:0042592
GO:0042976
GO:0043066
GO:0043167
GO:0043226
GO:0043235
GO:0046872
GO:0048856
GO:0048861
GO:0060397
GO:0065003
GO:0120162
HMNXSV003029258
HMNXSV003039519
HMNXSV003056739
Hs.166658.0.A1_3p_at
Hs.166658.0.A1_3p_x_at
Hs.1906.2.S1_3p_s_at
Hs.25252.0.S1_3p_at
Hs.35156.0.S1_3p_at
ILMN_1669781
ILMN_2175236
M31661_at
PH_hs_0023090
PH_hs_0041165
TC05001261.hg
TC05002950.hg
g13605397_3p_s_at
g4506106_3p_at
Participates
as a component of
p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y611-PRLR [endosome lumen]
PRLR [plasma membrane]
Inferred To
phospho-Prlr [plasma membrane]
(Mus musculus)
phospho-Prlr [plasma membrane]
(Rattus norvegicus)
phospho-prlra [plasma membrane]
(Danio rerio)
phospho-PRLR [plasma membrane]
(Bos taurus)
phospho-PRLR [plasma membrane]
(Canis familiaris)
Modified Residues
Name
O4'-phospho-L-tyrosine at 611
Coordinate
611
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000940.1
,
NP_001191243.1
,
XP_016865135.1
,
XP_006714547.1
,
NP_001191247.1
,
XP_011512371.1
,
XP_011512370.1
,
NP_001191246.1
,
NP_001191244.1
,
NP_001191245.1
Guide to Pharmacology - Targets
1721
OpenTargets
ENSG00000113494
ZINC - Substances
PRLR_HUMAN
ZINC target
P16471
PRO
P16471
GlyGen
P16471
PDB
1BP3
,
3NCF
,
2N7I
,
3NCE
,
3MZG
,
2LFG
,
3NCC
,
4I18
,
3N06
,
3D48
,
3NCB
,
3N0P
GeneCards
P16471
HPA
ENSG00000113494-PRLR
Ensembl
ENST00000231423
,
ENST00000514088
,
ENSP00000422556
,
ENST00000348262
,
ENSP00000425300
,
ENST00000620785
,
ENSP00000424841
,
ENST00000513753
,
ENSP00000422935
,
ENSP00000484768
,
ENST00000619676
,
ENST00000509140
,
ENSP00000441813
,
ENST00000511486
,
ENSP00000309008
,
ENSG00000113494
,
ENSP00000482954
,
ENSP00000231423
,
ENSP00000482689
,
ENST00000310101
,
ENST00000618457
,
ENSP00000311613
,
ENST00000542609
Pharos - Targets
P16471
Orphanet
22809
ZINC - Predictions - Purchasable
PRLR_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5U4 INSIG2
1
INSIG2 [endoplasmic reticulum membrane]
(R-HSA-1655736)
0.556
3
UniProt:Q8IY26 PLPP6
1
PLPP6 [plasma membrane]
(R-HSA-8952144)
0.556
3
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