Reactome | p-Y611-PRLR [plasma membrane]

p-Y611-PRLR [plasma membrane]

Stable Identifier

R-HSA-1369104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p(Y611)-PRLR, Prolactin receptor, PRLR_HUMAN, PRLR

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Prolactin receptor signaling (Homo sapiens)
    - PRLR binds SCF beta-TrCP complex (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - PRLR binds SHP2 (PTPN11) (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - PRLR binds STAT5 (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - PRLR is phosphorylated at Ser-349 (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - PRLR-bound STAT5 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - Prolactin receptor is internalized (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(S349)-PRLR:JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - SHP2 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)
    - Tyrosine phosphorylation of PRLR (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        p(Y611)-PRLR:p(Y1007)-JAK2 [plasma membrane] (Homo sapiens)
        
        p-Y611-PRLR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16471 PRLR

Gene Names

PRLR

Chain

signal peptide:1-24, chain:25-622

Reference Genes

BioGPS Gene:5618 PRLR

COSMIC (genes):PRLR PRLR

CTD Gene:5618 PRLR

dbSNP Gene:5618 PRLR

ENSEMBL:ENSG00000113494 PRLR

HGNC:9446 PRLR

KEGG Gene (Homo sapiens):5618 PRLR

Monarch:5618 PRLR

NCBI Gene:5618 PRLR

OMIM:176761 PRLR

UCSC:P16471 PRLR

Reference Transcript

Other Identifiers

0006860048

0104280132

1078_at

1079_g_at

11723501_at

11723502_at

11723503_at

11753026_a_at

11760771_a_at

16995177

206346_at

210476_s_at

211917_s_at

216638_s_at

227629_at

231981_at

243755_at

2853099

2853100

2853101

2853103

2853104

2853105

2853106

2853107

2853108

2853109

2853110

2853111

2853112

2853113

2853114

2853115

2853116

2853117

2853118

2853119

2853120

2853121

2853122

2853123

2853124

2853125

2853133

2853135

2853136

2853137

2853138

2853139

2853148

2853167

2853168

42824_at

43933_at

5618

56729_at

75460_at

8111490

81772_at

82529_r_at

A_23_P167468

A_24_P40737

A_24_P671164

A_33_P3416757

GE55950

GE57926

GE701898

GO:0000003

GO:0003674

GO:0004896

GO:0004923

GO:0004924

GO:0004925

GO:0005127

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005737

GO:0005768

GO:0005886

GO:0006464

GO:0006629

GO:0006694

GO:0006810

GO:0007165

GO:0007171

GO:0007566

GO:0007595

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0009897

GO:0009986

GO:0016020

GO:0016021

GO:0017046

GO:0019221

GO:0019955

GO:0022607

GO:0031410

GO:0031904

GO:0032991

GO:0038161

GO:0038165

GO:0042592

GO:0042976

GO:0043066

GO:0043167

GO:0043226

GO:0043235

GO:0046872

GO:0048856

GO:0048861

GO:0060397

GO:0065003

GO:0120162

HMNXSV003029258

HMNXSV003039519

HMNXSV003056739

Hs.166658.0.A1_3p_at

Hs.166658.0.A1_3p_x_at

Hs.1906.2.S1_3p_s_at

Hs.25252.0.S1_3p_at

Hs.35156.0.S1_3p_at

ILMN_1669781

ILMN_2175236

M31661_at

PH_hs_0023090

PH_hs_0041165

TC05001261.hg

TC05002950.hg

g13605397_3p_s_at

g4506106_3p_at

Participates

as a component of

Other forms of this molecule

p-Y611-PRLR [endosome lumen]

PRLR [plasma membrane]

Inferred To

phospho-Prlr [plasma membrane] (Mus musculus)

phospho-Prlr [plasma membrane] (Rattus norvegicus)

phospho-prlra [plasma membrane] (Danio rerio)

phospho-PRLR [plasma membrane] (Bos taurus)

phospho-PRLR [plasma membrane] (Canis familiaris)

Modified Residues

Name

O4'-phospho-L-tyrosine at 611

Coordinate

611

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_000940.1, NP_001191243.1, XP_016865135.1, XP_006714547.1, NP_001191247.1, XP_011512371.1, XP_011512370.1, NP_001191246.1, NP_001191244.1, NP_001191245.1

Guide to Pharmacology - Targets

1721

OpenTargets

ENSG00000113494

ZINC - Substances

PRLR_HUMAN

ZINC target

P16471

PRO

P16471

GlyGen

P16471

PDB

1BP3, 3NCF, 2N7I, 3NCE, 3MZG, 2LFG, 3NCC, 4I18, 3N06, 3D48, 3NCB, 3N0P

GeneCards

P16471

HPA

ENSG00000113494-PRLR

Ensembl

ENST00000231423, ENST00000514088, ENSP00000422556, ENST00000348262, ENSP00000425300, ENST00000620785, ENSP00000424841, ENST00000513753, ENSP00000422935, ENSP00000484768, ENST00000619676, ENST00000509140, ENSP00000441813, ENST00000511486, ENSP00000309008, ENSG00000113494, ENSP00000482954, ENSP00000231423, ENSP00000482689, ENST00000310101, ENST00000618457, ENSP00000311613, ENST00000542609

Pharos - Targets

P16471

Orphanet

22809

ZINC - Predictions - Purchasable

PRLR_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5U4 INSIG2	1	INSIG2 [endoplasmic reticulum membrane] (R-HSA-1655736)	0.556	3
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3

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