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INSIG2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-1655736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Insulin-induced gene 2 protein, INSI2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)
INSIG:oxysterol [endoplasmic reticulum membrane] (Homo sapiens)
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
INSIG2 [endoplasmic reticulum membrane] (Homo sapiens)
SREBP1A,1C,2:SCAP:INSIG:oxysterol [endoplasmic reticulum membrane] (Homo sapiens)
INSIG:oxysterol [endoplasmic reticulum membrane] (Homo sapiens)
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
INSIG2 [endoplasmic reticulum membrane] (Homo sapiens)
SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
INSIG2 [endoplasmic reticulum membrane] (Homo sapiens)
SREBP1A,1C,2:SCAP:cholesterol:INSIG [endoplasmic reticulum membrane] (Homo sapiens)
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
INSIG2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5U4 INSIG2
Gene Names
INSIG2
Chain
chain:1-225
Reference Genes
BioGPS Gene:51141 INSIG2
COSMIC (genes):INSIG2 INSIG2
CTD Gene:51141 INSIG2
dbSNP Gene:51141 INSIG2
ENSEMBL:ENSG00000125629 INSIG2
HGNC:20452 INSIG2
Monarch:51141 INSIG2
NCBI Gene:51141 INSIG2
OMIM:608660 INSIG2
UCSC:Q9Y5U4 INSIG2
Reference Transcript
RefSeq:NM_001321331.1 INSIG2
RefSeq:NM_001321330.1 INSIG2
RefSeq:NM_001321333.1 INSIG2
RefSeq:NM_001321332.1 INSIG2
RefSeq:NM_001321329.1 INSIG2
RefSeq:NM_016133.3 INSIG2
Other Identifiers
11719141_a_at
11719142_a_at
11719143_x_at
16884918
209566_PM_at
209566_at
2502426
2502427
2502428
2502430
2502431
2502432
2502437
2502439
2502440
2502446
2502447
2502449
2502450
2502451
2502452
2502453
2502454
2502455
35833_at
51141
8044766
A_14_P201254
A_23_P102454
A_24_P944458
A_33_P3321342
GE56357
GE566449
GO:0005515
GO:0005783
GO:0005789
GO:0006629
GO:0006641
GO:0006695
GO:0006991
GO:0008142
GO:0008203
GO:0008289
GO:0010894
GO:0016020
GO:0016126
GO:0032869
GO:0032933
GO:0032937
GO:0036316
GO:0042472
GO:0042474
GO:0043226
GO:0045717
GO:0048856
GO:0060021
GO:0060363
GO:0140311
GO:0140313
HMNXSV003050504
Hs.7089.0.S2_3p_at
ILMN_1676629
PH_hs_0000720
TC02000748.hg
Participates
as a component of
INSIG2:oxysterol [endoplasmic reticulum membrane] (Homo sapiens)
as a member of
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
Cross References
ENSEMBL
ENST00000245787
,
ENSP00000245787
OpenTargets
ENSG00000125629
HPA
ENSG00000125629-INSIG2
PRO
Q9Y5U4
Pharos - Targets
Q9Y5U4
HMDB Protein
HMDBP12298
PDB
4J82
,
6M49
,
7ETW
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15151 PVR
1
PVR [plasma membrane]
(R-HSA-420600)
0.556
3
UniProt:Q99437 ATP6V0B
3
ATP6V0B [endosome membrane]
(R-HSA-912584)
ATP6V0B [phagocytic vesicle membrane]
(R-HSA-1222695)
ATP6V0B [lysosomal membrane]
(R-HSA-9640187)
0.556
3
UniProt:P16471 PRLR
3
p-Y611-PRLR [plasma membrane]
(R-HSA-1369104)
PRLR [plasma membrane]
(R-HSA-976964)
p-Y611-PRLR [endosome lumen]
(R-HSA-2002376)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
UniProt:Q8TB40 ABHD4
1
ABHD4 [endoplasmic reticulum membrane]
(R-HSA-5694582)
0.556
3
UniProt:Q8TF71 SLC16A10
1
SLC16A10 [plasma membrane]
(R-HSA-352147)
0.556
3
UniProt:O60883 GPR37L1
1
GPR37L1 [plasma membrane]
(R-HSA-5336178)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
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