Reactome | UVRAG complex [cytosol]

UVRAG complex [cytosol]

Stable Identifier

R-HSA-5683632

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

UVRAG:PIK3C3:PIK3R4:BECN1, Uvrag:Vps34:Vps15:Beclin-1

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General

The PIK3C3-containing Beclin-1 complex consists of PIK3C3 (Vps34), BECN1 (Beclin-1, Atg6), PIK3R4 (p150, Vps15) and ATG14 (Barkor) (Matsunaga et al. 2009, Zhong et al. 2009). A similar complex where ATG14 is replaced by UVRAG functions later in autophagosome maturation and endocytic traffic (Itakura et al. 2008, Liang et al. 2008). Binding of KIAA0226 to this complex negatively regulates the maturation process (Matsunaga et al. 2009).

Participants

components