Activated CEBPB stimulates transcription of CDKN2B

Stable Identifier
R-HSA-3857348
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Activated CEBPB stimulates transcription of CDKN2B
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Once bound to the CDKN2B promoter, CEBPB stimulates CKDN2B transcription, contributing to cell cycle arrest in oncogene induced senescence (Kuilman et al. 2008). In addition, since CEBPB expression is stimulated by IL6 signaling, with IL6 itself being a transcriptional target of CEBPB (Neihof et al. 2001, Kuilman et al. 2008, Lee et al. 2010), IL6-CEBPB-CDKN2B axis provides an autocrine SASP-mediated growth arrest mechanism.

Literature References
PubMed ID Title Journal Year
18555778 Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

Kuilman, T, Mooi, WJ, Douma, S, Aarden, LA, van Doorn, R, Michaloglou, C, Peeper, DS, Vredeveld, LC, Desmet, CJ

Cell 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-T235,S321-CEBPB:CDKN2B Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-T235,S321-CEBPB homodimer [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-07-09)
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