SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B

Stable Identifier
R-HSA-2187303
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
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SMAD2/3:SMAD4:SP1 complex binds SP1 and SMAD promoter elements of CDKN2B (p15-INK4B) gene and stimulates transcription of CDKN2B. CDKN2B inhibits the action of cyclin-dependent kinases CDK4 and CDK6 and may be an effector of TGF-beta induced cell cycle arrest (Feng et al. 2000).

Literature References
PubMed ID Title Journal Year
11013220 Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

Lin, X, Feng, XH, Derynck, R

EMBO J 2000
Participants
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Output
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as an event of
This event is regulated
Positively by
Regulator
p-2S-SMAD2,3:SMAD4:SP1:CDKN2B gene [nucleoplasm] (Homo sapiens)
Active Unit
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2012-04-04)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-09)
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