Reactome | MED15 [nucleoplasm]

MED15 [nucleoplasm]

Stable Identifier

R-HSA-556827

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 15, MED15_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED15 [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED15 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96RN5 MED15

Gene Names

MED15, ARC105, CTG7A, PCQAP, TIG1, TNRC7

Chain

chain:1-788

Reference Genes

BioGPS Gene:51586 MED15

COSMIC (genes):MED15 MED15

CTD Gene:51586 MED15

dbSNP Gene:51586 MED15

ENSEMBL:ENSG00000099917 MED15

HGNC:14248 MED15

KEGG:hsa:51586 MED15

Monarch:51586 MED15

NCBI Gene:51586 MED15

OMIM:607372 MED15

UCSC:Q96RN5 MED15

Reference Transcript

Participates

as a component of

as an input of

Formation of ARC coactivator complex (Homo sapiens)

Inferred To

MED15 [nucleoplasm] (Bos taurus)

MED15 [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000099917

ENSEMBL

ENSG00000099917, ENSP00000372434, ENSP00000292733, ENSP00000263205, ENST00000382974, ENST00000292733, ENST00000263205

HPA

ENSG00000099917-MED15

GeneCards

MED15

PRO

Q96RN5

Pharos - Targets

Q96RN5

GlyGen

Q96RN5

PDB

7LBM, 8GXS, 8GXQ, 7ENJ, 7ENA, 7ENC, 8TQW, 8TRH, 2GUT, 8J9A, 7EMF, 8T9D

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.884	15
UniProt:P36956-1 SREBF1	5	SREBF1-1 [endoplasmic reticulum membrane] (R-HSA-1655757) SREBF1-1 [Golgi membrane] (R-HSA-1655753) SREBF1-1(1-530) [Golgi membrane] (R-HSA-1655718) SREBF1-1(1-490) [cytosol] (R-HSA-1655764) SREBF1-1(1-490) [nucleoplasm] (R-HSA-1655755)	0.747	7
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.744	4
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.725	5
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.71	5
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.643	5
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.643	5
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.564	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.527	4
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	3
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.527	2
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.527	3
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.527	4
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.527	3
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.527	3
UniProt:P61088 UBE2N	5	UBE2N [cytosol] (R-HSA-206072) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [nucleoplasm] (R-HSA-5682541) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013)	0.508	2
UniProt:P36956-3 SREBF1	5	SREBF1-3 [nucleoplasm] (R-HSA-1655716) SREBF1-3 [endoplasmic reticulum membrane] (R-HSA-1655761) SREBF1-3 [Golgi membrane] (R-HSA-1655760) SREBF1-3 [Golgi membrane] (R-HSA-1655724) SREBF1-3 [cytosol] (R-HSA-1655721)	0.499	2
UniProt:Q12772 SREBF2	5	SREBF2(1-1141) [Golgi membrane] (R-HSA-1655747) SREBF2(1-522) [Golgi membrane] (R-HSA-1655752) SREBF2(1-484) [cytosol] (R-HSA-1655723) SREBF2(1-1141) [endoplasmic reticulum membrane] (R-HSA-1655733) SREBF2(1-484) [nucleoplasm] (R-HSA-1655745)	0.499	2
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.483	2
UniProt:Q96F44 TRIM11	1	TRIM11 [cytosol] (R-HSA-976033)	0.463	5

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