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SREBP1A,1C,2 dimer [nucleoplasm]
Stable Identifier
R-HSA-1655744
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SREBF1A,1C,2 dimer
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of ELOVL6 (Homo sapiens)
SREBP1A,1C,2:ELOVL6 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
Expression of TM7SF2 (Homo sapiens)
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the ELOVL6 promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:ELOVL6 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 translocates to the nucleus (Homo sapiens)
SREBP1A,1C,2:Importin beta-1 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:Importin beta-1 dissociates (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:Importin beta-1 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
9634703
Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution
Párraga, A
,
Bellsolell, L
,
Ferré-D'Amaré, AR
,
Burley, SK
Structure
1998
Participants
components
2 x
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
Participant Of
hasComponent
SREBP1A,1C,2:ELOVL6 gene [nucleoplasm]
SREBP1A,1C,2:Importin beta-1 [nucleoplasm]
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm]
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm]
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm]
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm]
input
SREBP1A,1C,2 binds the ELOVL6 promoter
SREBP1A,1C,2 binds the FDFT1 promoter
SREBP1A,1C,2 binds the FDPS promoter
SREBP1A,1C,2 binds the HMGCS1 promoter
SREBP1A,1C,2 binds the TM7SF2 promoter
output
SREBP1A,1C,2:Importin beta-1 dissociates
Inferred To
SREBP1A,1C,2 dimer [nucleoplasm] (Bos taurus)
SREBP1A,1C,2 dimer [nucleoplasm] (Caenorhabditis elegans)
SREBP1A,1C,2 dimer [nucleoplasm] (Canis familiaris)
SREBP1A,1C,2 dimer [nucleoplasm] (Danio rerio)
SREBP1A,1C,2 dimer [nucleoplasm] (Drosophila melanogaster)
SREBP1A,1C,2 dimer [nucleoplasm] (Gallus gallus)
SREBP1A,1C,2 dimer [nucleoplasm] (Mus musculus)
SREBP1A,1C,2 dimer [nucleoplasm] (Rattus norvegicus)
SREBP1A,1C,2 dimer [nucleoplasm] (Sus scrofa)
SREBP1A,1C,2 dimer [nucleoplasm] (Xenopus tropicalis)
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