SREBP1A,1C,2 binds the FDPS promoter

Stable Identifier
Reaction [binding]
Homo sapiens
SREBF1A,1C,2 binds the FDPS promoter
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SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the FDPS gene (Ericsson et al. 1996, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008, Rome et al. 2008, Ishimoto et al. 2010). The binding of NF-Y synergistically enhances the binding of SREBP1 (Ericsson et al. 1996). SREBP1A activates FDPS more strongly than does SREBP2 or SREBP1C (Amemiya-Kudo et al. 2002).

Literature References
PubMed ID Title Journal Year
18559965 Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Euthine, V, Lefai, E, Meugnier, E, Vidal, H, Debard, C, Rome, S, Rieusset, J, Lecomte, V

Physiol Genomics 2008
12177166 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

Matsuzaka, T, Amemiya-Kudo, M, Ohashi, K, Yamada, N, Kimura, S, Tamura, Y, Yoshikawa, T, Yahagi, N, Harada, K, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Sato, R, Gotoda, T, Hasty, AH, Osuga, J

J Lipid Res 2002
18654640 Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes

Szekely, AM, Weissman, SM, Reed, BD, Snyder, M, Charos, AE

PLoS Genet 2008
20450493 Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells

Hanano, I, Doi, T, Kawai, M, Nakamura, H, Tanaka, T, Hamakubo, T, Tachibana, K, Urano, Y, Yamasaki, D, Sakai, J, Ishimoto, K, Kodama, T

Biochem J 2010
8798690 Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene

Edwards, PA, Ericsson, J, Jackson, SM

J Biol Chem 1996
9748295 Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

Brown, MS, Pai, JT, Guryev, O, Goldstein, JL

J Biol Chem 1998
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