SREBP1A,1C,2 binds the TM7SF2 promoter

Stable Identifier
R-HSA-2065966
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Formation of SREBF:NF-Y:TM7SF2 gene complex, Formation of SREBP:NF-Y:TM7SF2 gene complex
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SREBP1A,1C,2 binds the TM7SF2 promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).

Literature References
PubMed ID Title Journal Year
18559965 Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Euthine, V, Lefai, E, Meugnier, E, Vidal, H, Debard, C, Rome, S, Rieusset, J, Lecomte, V

Physiol Genomics 2008
18654640 Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes

Szekely, AM, Weissman, SM, Reed, BD, Snyder, M, Charos, AE

PLoS Genet 2008
20138239 Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box

Roberti, R, Castelli, M, Bennati, AM, Servillo, G, Beccari, T, Fazia, MA, Schiavoni, G

Biochim Biophys Acta 2010
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2012-01-24)
Reviewed
Liang, G  (2012-08-26)
Created
May, B  (2012-01-25)
Cite Us!