SREBP1A,1C,2 binds the HMGCS1 promoter

Stable Identifier
Reaction [binding]
Homo sapiens
SREBF1A,1C,2 binds the HMGCS1 promoter
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SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).

Literature References
PubMed ID Title Journal Year
12177166 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

Matsuzaka, T, Amemiya-Kudo, M, Ohashi, K, Yamada, N, Kimura, S, Tamura, Y, Yoshikawa, T, Yahagi, N, Harada, K, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Sato, R, Gotoda, T, Hasty, AH, Osuga, J

J Lipid Res 2002
18654640 Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes

Szekely, AM, Weissman, SM, Reed, BD, Snyder, M, Charos, AE

PLoS Genet 2008
9604010 Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase

Inoue, J, Sato, R, Maeda, M

J Biochem 1998
9748295 Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

Brown, MS, Pai, JT, Guryev, O, Goldstein, JL

J Biol Chem 1998
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