Reactome | SREBP1A,1C,2 binds the FDFT1 promoter

SREBP1A,1C,2 binds the FDFT1 promoter

Stable Identifier

R-HSA-2426146

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SREBF1A,1C,2 binds the FDFT1 promoter

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SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y and SP1, bind and transactivate the promoter of the FDFT1 gene (Inoue et al. 1998, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates FDFT1 more strongly than does SREBP1A (Pai et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
18654640	Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes Reed, BD, Charos, AE, Szekely, AM, Weissman, SM, Snyder, M	PLoS Genet	2008
18559965	Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle Rome, S, Lecomte, V, Meugnier, E, Rieusset, J, Debard, C, Euthine, V, Vidal, H, Lefai, E	Physiol Genomics	2008
9604010	Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase Inoue, J, Sato, R, Maeda, M	J Biochem	1998
9748295	Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins Pai, JT, Guryev, O, Brown, MS, Goldstein, JL	J Biol Chem	1998

Participants

Input

Output

SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Activation of gene expression by SREBF (SREBP)

Authored

May, B (2012-07-26)

Reviewed

Liang, G (2012-08-26)

Created

May, B (2012-07-27)