Reactome | PDE3B [cytosol]

PDE3B [cytosol]

Stable Identifier

R-HSA-162348

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 3B

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - PDE3B hydrolyses cAMP to AMP (Homo sapiens)
        
        PDE3B [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        PKB-mediated events (Homo sapiens)
        
        PDE3B signalling (Homo sapiens)
        
        p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)
        
        PDE3B [cytosol] (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        PKB-mediated events (Homo sapiens)
        
        PDE3B signalling (Homo sapiens)
        
        p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)
        
        PDE3B [cytosol] (Homo sapiens)

General

Can hydrolyze both cAMP and cGMP

External Reference Information

External Reference

UniProt:Q13370 PDE3B

Gene Names

PDE3B

Chain

chain:1-1112

Reference Genes

BioGPS Gene:5140 PDE3B

COSMIC (genes):PDE3B PDE3B

CTD Gene:5140 PDE3B

dbSNP Gene:5140 PDE3B

ENSEMBL:ENSG00000152270 PDE3B

HGNC:8779 PDE3B

KEGG:hsa:5140 PDE3B

Monarch:5140 PDE3B

NCBI Gene:5140 PDE3B

OMIM:602047 PDE3B

UCSC:Q13370 PDE3B

Reference Transcript

RefSeq:NM_000922.3 PDE3B

Other Identifiers

11730472_a_at

11730473_at

11730474_at

16722299

16722321

208591_3p_s_at

208591_PM_s_at

208591_s_at

214582_PM_at

214582_at

222317_PM_at

222317_at

3321521

3321522

3321523

3321524

3321525

3321526

3321542

3321543

3321544

3321547

3321548

3321549

3321550

3321552

3321554

3321555

3321556

3321559

3321560

3321561

3321562

3321563

3321564

3321567

3321569

3321572

3321573

3321575

3321576

3321577

3321578

3321579

3321580

3321581

3321584

3321585

35872_at

43859_g_at

5140

746_at

7938629

81314_r_at

84101_at

A_14_P128647

A_23_P116114

A_33_P3240018

D50640_at

GE550976

GE60175

GE60484

GO:0001525

GO:0003824

GO:0004114

GO:0004115

GO:0004119

GO:0005515

GO:0005783

GO:0005794

GO:0005829

GO:0007162

GO:0007165

GO:0007186

GO:0008081

GO:0016020

GO:0016525

GO:0016787

GO:0019933

GO:0032045

GO:0032869

GO:0033629

GO:0043226

GO:0043422

GO:0045765

GO:0046872

GO:0047555

GO:0050995

GO:0051896

GO:0106072

HMNXSV003010565

HMNXSV003014494

Hs.118567.0.A1_3p_at

Hs.150741.3.S2_3p_at

ILMN_2131381

PH_hs_0016568

TC11000214.hg

g4505660_3p_at

g4505660_3p_s_at

Participates

as an input of

p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)

Other forms of this molecule

p-S295-PDE3B [cytosol]

Inferred To

pde3b [cytosol] (Xenopus tropicalis)

Homologues of PDE3B [cytosol] (Dictyostelium discoideum)

Homologues of PDE3B [cytosol] (Plasmodium falciparum)

PDE3B [cytosol] (Bos taurus)

PDE3B [cytosol] (Caenorhabditis elegans)

PDE3B [cytosol] (Canis familiaris)

PDE3B [cytosol] (Dictyostelium discoideum)

PDE3B [cytosol] (Gallus gallus)

PDE3B [cytosol] (Mus musculus)

PDE3B [cytosol] (Plasmodium falciparum)

PDE3B [cytosol] (Rattus norvegicus)

PDE3B [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_000913.2

ZINC - World Drugs

PDE3B_HUMAN

Guide to Pharmacology - Targets

1299

OpenTargets

ENSG00000152270

ENSEMBL

ENST00000282096, ENSP00000388644, ENSP00000282096, ENST00000455098

ZINC - FDA approved

PDE3B_HUMAN

ZINC - Substances

PDE3B_HUMAN

ZINC - Biogenic

PDE3B_HUMAN

ZINC target

Q13370

PRO

Q13370

PDB

1SOJ, 8SYC, 1SO2

ZINC - Investigational

PDE3B_HUMAN

IntEnz

3.1.4.17

HPA

ENSG00000152270-PDE3B

Pharos - Targets

Q13370

ZINC - Predictions - Purchasable

PDE3B_HUMAN

HMDB Protein

HMDBP00578

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95398 RAPGEF3	1	RAPGEF3 [plasma membrane] (R-HSA-3008670)	0.644	8
UniProt:Q5UE93 PIK3R6	1	PIK3R6 [cytosol] (R-HSA-425642)	0.591	3
UniProt:O60760 HPGDS	1	HPGDS [cytosol] (R-HSA-2142706)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:P01911 HLA-DRB1	9	HLA class II histocompatibility antigen, DRB1-15 beta chain [plasma membrane] (R-HSA-197644) HLA class II histocompatibility antigen, DRB1-15 beta chain [lysosomal membrane] (R-HSA-2130363) HLA class II histocompatibility antigen, DRB1-15 beta chain [endocytic vesicle membrane] (R-HSA-2130448) HLA class II histocompatibility antigen, DRB1-15 beta chain [clathrin-coated endocytic vesicle membrane] (R-HSA-2130587) HLA class II histocompatibility antigen, DRB1-15 beta chain [transport vesicle membrane] (R-HSA-2130626) HLA class II histocompatibility antigen, DRB1-15 beta chain [trans-Golgi network membrane] (R-HSA-2130737) HLA class II histocompatibility antigen, DRB1-15 beta chain [Golgi membrane] (R-HSA-2214371) HLA class II histocompatibility antigen, DRB1-15 beta chain [ER to Golgi transport vesicle membrane] (R-HSA-2130344) HLA class II histocompatibility antigen, DRB1-15 beta chain [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130328)	0.527	2
UniProt:Q8WWF5 ZNRF4			0.527	2
UniProt:O15482 TEX28			0.527	2
UniProt:Q6P9F7 LRRC8B	1	LRRC8B [plasma membrane] (R-HSA-8941535)	0.527	2
UniProt:Q9BQ31 KCNS3	1	KCNS3 [plasma membrane] (R-HSA-381709)	0.527	2
UniProt:Q96K19 RN170			0.527	2
UniProt:Q86UE6 LRRTM1	1	LRRTM1 [plasma membrane] (R-HSA-6797964)	0.527	2
UniProt:Q9Y6I9 TEX264	2	TEX264 [platelet alpha granule lumen] (R-HSA-8863000) TEX264 [extracellular region] (R-HSA-8863002)	0.527	3
UniProt:P48736 PIK3CG	1	PIK3CG [cytosol] (R-HSA-392286)	0.499	3