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RAPGEF3 [plasma membrane]
Stable Identifier
R-HSA-3008670
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EPAC1, Rap guanine nucleotide exchange factor 3
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Activation of Rap1 by membrane-associated GEFs (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Rap1 signalling (Homo sapiens)
Activation of EPACs by cAMP (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
Rap1 cAMP-GEFs:cAMP [cytosol] (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
Activation of Rap1 by membrane-associated GEFs (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
RAP1A exchanges GDP for GTP (Homo sapiens)
RAPGEF3:cAMP complex [plasma membrane] (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
cAMP activates EPAC1 (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
RAPGEF3:cAMP complex [plasma membrane] (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)
RAPGEF3:cAMP complex [plasma membrane] (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Activation of Rap1 by membrane-associated GEFs (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95398 RAPGEF3
Gene Names
RAPGEF3, CGEF1, EPAC, EPAC1
Chain
chain:1-923
Reference Genes
BioGPS Gene:10411 RAPGEF3
COSMIC (genes):RAPGEF3 RAPGEF3
CTD Gene:10411 RAPGEF3
dbSNP Gene:10411 RAPGEF3
ENSEMBL:ENSG00000079337 RAPGEF3
HGNC:16629 RAPGEF3
Monarch:10411 RAPGEF3
NCBI Gene:10411 RAPGEF3
OMIM:606057 RAPGEF3
UCSC:O95398 RAPGEF3
Reference Transcript
RefSeq:NM_001098532.2 RAPGEF3
RefSeq:NM_006105.5 RAPGEF3
Other Identifiers
10411
11725381_a_at
11725382_a_at
11752157_a_at
11760609_at
16763666
210051_PM_at
210051_at
215027_PM_at
215027_at
3452684
3452686
3452687
3452689
3452691
3452692
3452693
3452694
3452695
3452696
3452697
3452698
3452699
3452701
3452702
3452703
3452704
3452705
3452706
3452707
3452708
3452709
3452710
3452711
3452712
3452713
3452714
3452715
3452716
3452718
3452719
3452720
3452721
3452722
3452723
3452724
3452725
3452726
3452727
3452728
3452729
3452730
3452731
3452732
3452734
3452735
3452736
3452737
3452738
36266_at
40705_at
66794_at
7962623
7962625
A_23_P151307
A_32_P393316
A_33_P3389178
GE493976
GE59424
GO:0001525
GO:0002250
GO:0002376
GO:0005085
GO:0005515
GO:0005856
GO:0005886
GO:0005902
GO:0007165
GO:0007189
GO:0007264
GO:0007265
GO:0008306
GO:0012505
GO:0016020
GO:0019904
GO:0030027
GO:0030175
GO:0030552
GO:0030864
GO:0032486
GO:0032956
GO:0034242
GO:0035556
GO:0043226
GO:0043547
GO:0045765
GO:0045766
GO:0046827
GO:0048856
GO:0050796
GO:0050877
GO:0051496
GO:0051896
GO:0060143
GO:0061028
GO:0070062
GO:0071320
GO:0098772
HMNXSV003003192
HMNXSV003011781
HMNXSV003016143
HMNXSV003020537
Hs.27414.0.S1_3p_at
ILMN_2135258
PH_hs_0000909
PH_hs_0002434
PH_hs_0037765
TC12001437.hg
U79275_at
g4079648_3p_at
g4079648_3p_x_at
Participates
as a member of
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
as an input of
cAMP activates EPAC1 (Homo sapiens)
as a component of
RAPGEF3:cAMP complex [plasma membrane] (Homo sapiens)
Inferred To
gefP [plasma membrane]
(Dictyostelium discoideum)
ste6 [plasma membrane]
(Schizosaccharomyces pombe)
LTE1 [plasma membrane]
(Saccharomyces cerevisiae)
CDC25 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of RAPGEF3 [plasma membrane]
(Dictyostelium discoideum)
Homologues of RAPGEF3 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of RAPGEF3 [plasma membrane]
(Schizosaccharomyces pombe)
RAPGEF3 [plasma membrane]
(Bos taurus)
RAPGEF3 [plasma membrane]
(Caenorhabditis elegans)
RAPGEF3 [plasma membrane]
(Canis familiaris)
RAPGEF3 [plasma membrane]
(Gallus gallus)
RAPGEF3 [plasma membrane]
(Mus musculus)
RAPGEF3 [plasma membrane]
(Rattus norvegicus)
RAPGEF3 [plasma membrane]
(Sus scrofa)
rapgef3 [plasma membrane]
(Xenopus tropicalis)
efc25 [plasma membrane]
(Schizosaccharomyces pombe)
BUD5 [plasma membrane]
(Saccharomyces cerevisiae)
gefW [plasma membrane]
(Dictyostelium discoideum)
Epac [plasma membrane]
(Drosophila melanogaster)
Cross References
Guide to Pharmacology - Targets
1292
ENSEMBL
ENST00000449771
,
ENST00000395358
,
ENST00000405493
,
ENSP00000378764
,
ENSP00000384521
,
ENST00000549151
,
ENSP00000448619
,
ENST00000389212
,
ENSP00000373864
,
ENSP00000395708
OpenTargets
ENSG00000079337
HPA
ENSG00000079337-RAPGEF3
ZINC - Substances
RPGF3_HUMAN
ZINC target
O95398
PRO
O95398
Pharos - Targets
O95398
GlyGen
O95398
HMDB Protein
HMDBP02762
PDB
6H7E
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13370 PDE3B
2
p-S295-PDE3B [cytosol]
(R-HSA-162419)
PDE3B [cytosol]
(R-HSA-162348)
0.644
8
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