Reactome | PIK3R6 [cytosol]

PIK3R6 [cytosol]

Stable Identifier

R-HSA-425642

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PI3K-p84, Phosphoinositide 3-kinase regulatory subunit 6, PI3R6_HUMAN, C17orf38

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-stimulation by CD28 (Homo sapiens)
      - CD28 dependent PI3K/Akt signaling (Homo sapiens)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        PI3K binds CD28 (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
    - Co-stimulation by ICOS (Homo sapiens)
      - PI3K binds ICOS (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G-protein beta:gamma signalling (Homo sapiens)
      - G beta:gamma signalling through PI3Kgamma (Homo sapiens)
        
        G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
        
        G-protein beta-gamma:PI3K gamma [plasma membrane] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        Gbeta:gamma recruits PI3K gamma (Homo sapiens)
        
        G-protein beta-gamma:PI3K gamma [plasma membrane] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5UE93 PIK3R6

Gene Names

PIK3R6, C17orf38

Chain

chain:1-754

Reference Genes

BioGPS Gene:146850 PIK3R6

COSMIC (genes):PIK3R6 PIK3R6

CTD Gene:146850 PIK3R6

dbSNP Gene:146850 PIK3R6

ENSEMBL:ENSG00000276231 PIK3R6

HGNC:27101 PIK3R6

KEGG:hsa:146850 PIK3R6

Monarch:146850 PIK3R6

NCBI Gene:146850 PIK3R6

OMIM:611462 PIK3R6

UCSC:Q5UE93 PIK3R6

Reference Transcript

Other Identifiers

11735599_a_at

146850

1558770_PM_a_at

1558770_a_at

16841060

3744631

3744632

3744633

3744634

3744635

3744637

3744639

3744643

3744644

3744646

3744649

3744651

3744652

3744654

3744655

3744656

3744658

3744659

3744660

3744661

3744662

3744663

3744664

3744665

3744666

3744667

3744668

3744670

3744673

3744676

8012539

A_24_P366509

GE695458

GO:0001525

GO:0002376

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0005944

GO:0006955

GO:0007186

GO:0016020

GO:0016740

GO:0042269

GO:0043406

GO:0045582

GO:0045766

GO:0046934

GO:0046935

GO:0098772

HMNXSV003012762

Hs2.255809.1.S1_3p_a_at

Hs2.255809.1.S1_3p_s_at

ILMN_1783645

PH_hs_0013467

TC17001123.hg

p6671

Participates

as a component of

PIK3CG:PIK3R6 [cytosol] (Homo sapiens)

as a member of

PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)

Inferred To

PIK3R6 [cytosol] (Bos taurus)

PIK3R6 [cytosol] (Canis familiaris)

PIK3R6 [cytosol] (Dictyostelium discoideum)

PIK3R6 [cytosol] (Gallus gallus)

PIK3R6 [cytosol] (Sus scrofa)

Pik3r6 [cytosol] (Mus musculus)

Pik3r6 [cytosol] (Rattus norvegicus)

pik3r6 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001010855.1, XP_016879718.1

Guide to Pharmacology - Targets

2507

ENSEMBL

ENSP00000480157, ENST00000619866, ENSG00000276231

OpenTargets

ENSG00000276231

GeneCards

PIK3R6

HPA

ENSG00000276231-PIK3R6

PRO

Q5UE93

Pharos - Targets

Q5UE93

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13370 PDE3B	2	p-S295-PDE3B [cytosol] (R-HSA-162419) PDE3B [cytosol] (R-HSA-162348)	0.591	3

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