Reactome | PIK3R6 [cytosol]

PIK3R6 [cytosol]

Stable Identifier

R-HSA-425642

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PI3K-p84, Phosphoinositide 3-kinase regulatory subunit 6, PI3R6_HUMAN, C17orf38

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G-protein beta:gamma signalling (Homo sapiens)
      - G beta:gamma signalling through PI3Kgamma (Homo sapiens)
        
        G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)
        
        G-protein beta-gamma:PI3K gamma [plasma membrane] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        Gbeta:gamma recruits PI3K gamma (Homo sapiens)
        
        G-protein beta-gamma:PI3K gamma [plasma membrane] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)
        
        PIK3R6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5UE93 PIK3R6

Gene Names

PIK3R6, C17orf38

Chain

chain:1-754

Reference Genes

BioGPS Gene:146850 PIK3R6

COSMIC (genes):PIK3R6 PIK3R6

CTD Gene:146850 PIK3R6

dbSNP Gene:146850 PIK3R6

ENSEMBL:ENSG00000276231 PIK3R6

ENSEMBL_homo_sapiens_GENE:ENSG00000276231.5 PIK3R6

HGNC:27101 PIK3R6

KEGG Gene (Homo sapiens):146850 PIK3R6

Monarch:146850 PIK3R6

NCBI Gene:146850 PIK3R6

OMIM:611462 PIK3R6

UCSC:Q5UE93 PIK3R6

Reference Transcript

Other Identifiers

11735599_a_at

146850

1558770_PM_a_at

1558770_a_at

16841060

3744631

3744632

3744633

3744634

3744635

3744639

3744643

3744644

3744646

3744649

3744651

3744652

3744654

3744655

3744656

3744658

3744659

3744660

3744661

3744662

3744663

3744665

3744666

3744668

3744670

3744673

3744676

8012539

A_24_P366509

GE695458

GO:0001525

GO:0002376

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0005944

GO:0006955

GO:0007155

GO:0007186

GO:0016020

GO:0016740

GO:0023052

GO:0030154

GO:0036211

GO:0042269

GO:0043406

GO:0045582

GO:0045766

GO:0046934

GO:0046935

GO:0048856

GO:0098542

GO:0098772

HMNXSV003012762

Hs2.255809.1.S1_3p_a_at

Hs2.255809.1.S1_3p_s_at

ILMN_1783645

PH_hs_0013467

TC17001123.hg

p6671

Participates

as a member of

PI3-kinase gamma, regulatory subunit [cytosol] (Homo sapiens)

as a component of

PIK3CG:PIK3R6 [cytosol] (Homo sapiens)

Inferred To

PIK3R6 [cytosol] (Bos taurus)

PIK3R6 [cytosol] (Canis familiaris)

PIK3R6 [cytosol] (Dictyostelium discoideum)

PIK3R6 [cytosol] (Gallus gallus)

PIK3R6 [cytosol] (Sus scrofa)

Pik3r6 [cytosol] (Mus musculus)

Pik3r6 [cytosol] (Rattus norvegicus)

pik3r6 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001010855.1, XP_016879718.1

Guide to Pharmacology - Targets

2507

OpenTargets

ENSG00000276231

HPA

ENSG00000276231-PIK3R6

GeneCards

Q5UE93

Ensembl

ENST00000619866, ENSP00000480157, ENSG00000276231

PRO

Q5UE93

Pharos - Targets

Q5UE93

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13370 PDE3B	2	p-S295-PDE3B [cytosol] (R-HSA-162419) PDE3B [cytosol] (R-HSA-162348)	0.591	3