Reactome | PLAT(36-562) [extracellular region]

PLAT(36-562) [extracellular region]

Stable Identifier

R-HSA-158754

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

PLAT, tissue plasminogen activator (one-chain)

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External Reference Information

External Reference

UniProt:P00750 PLAT

Gene Names

PLAT

Chain

signal peptide:1-22, propeptide:23-32, propeptide:33-35, chain:36-562, chain:36-310, chain:311-562

Reference Genes

BioGPS Gene:5327 PLAT

COSMIC (genes):PLAT PLAT

CTD Gene:5327 PLAT

dbSNP Gene:5327 PLAT

ENSEMBL:ENSG00000104368 PLAT

HGNC:9051 PLAT

KEGG Gene (Homo sapiens):5327 PLAT

Monarch:5327 PLAT

NCBI Gene:5327 PLAT

OMIM:173370 PLAT

UCSC:P00750 PLAT

Reference Transcript

Other Identifiers

0002640020

11715847_x_at

11732321_a_at

11747398_a_at

11747399_x_at

11749809_a_at

11753829_a_at

11754545_x_at

17076726

201860_s_at

3133234

3133235

3133236

3133241

3133242

3133244

3133245

3133246

3133247

3133248

3133249

3133251

3133252

3133254

3133256

3133257

3133259

3133260

3133263

3133264

3133269

33452_at

5327

8150509

A_23_P82868

GE80967

GE84488

GO:0001666

GO:0003674

GO:0004252

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006464

GO:0006508

GO:0006950

GO:0007165

GO:0007267

GO:0007596

GO:0008150

GO:0008233

GO:0008236

GO:0009986

GO:0014909

GO:0016787

GO:0030141

GO:0031410

GO:0031639

GO:0040011

GO:0042730

GO:0043226

GO:0045177

GO:0045861

GO:0048008

GO:0048870

GO:0051219

GO:0051604

GO:0070062

GO:0098685

GO:0098978

GO:0099183

ILMN_1738742

K03021_at

PH_hs_0014156

TC08001175.hg

TC08002306.hg

g4505860_3p_a_at

Participant Of

input

crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)

hasComponent

fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region]

hasMember

serine-type endopeptidases involved in novel PDGF processing [extracellular region]

Other forms of this molecule

PLAT(311-562) [extracellular region]

PLAT(36-310) [extracellular region]

Inferred To

Plat [extracellular region] (Mus musculus)

Plat [extracellular region] (Rattus norvegicus)

PLAT(36-562) [extracellular region] (Bos taurus)

plat [extracellular region] (Danio rerio)

plat [extracellular region] (Xenopus tropicalis)

PLAT [extracellular region] (Canis familiaris)

PLAT [extracellular region] (Gallus gallus)

PLAT [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000921.1, NP_001306118.1, NP_127509.1

OpenTargets

ENSG00000104368

ZINC - Substances

TPA_HUMAN

ZINC target

P00750

PRO

P00750

PDB

1BDA, 1TPK, 5ZLZ, 1TPG, 1PML, 1RTF, 1TPM, 5BRR, 1A5H, 1TPN, 1PK2

ZINC - Investigational

TPA_HUMAN

HPA

ENSG00000104368-PLAT

GeneCards

P00750

Ensembl

ENST00000352041, ENST00000220809, ENST00000429089, ENSG00000104368, ENSP00000220809, ENSP00000392045, ENSP00000270188

Orphanet

25493

ZINC - Predictions - Purchasable

TPA_HUMAN

HMDB Protein

HMDBP01868

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC8 NS8			0.527	2