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PLAT(36-562) [extracellular region]
Stable Identifier
R-HSA-158754
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
PLAT, tissue plasminogen activator (one-chain)
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Dissolution of Fibrin Clot (Homo sapiens)
PLG(20-810) binds anti-fibrinolytics (Homo sapiens)
PLG(20-810):anti-fibrinolytics [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
PLG(20-810) binds aprotinin (Homo sapiens)
PLG(20-810):aprotinin [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Extracellular processing of novel PDGFs (Homo sapiens)
serine-type endopeptidases involved in novel PDGF processing [extracellular region] (Homo sapiens)
PLAT(36-562) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00750 PLAT
Gene Names
PLAT
Chain
signal peptide:1-22, propeptide:23-32, propeptide:33-35, chain:36-562, chain:36-310, chain:311-562
Reference Genes
BioGPS Gene:5327 PLAT
COSMIC (genes):PLAT PLAT
CTD Gene:5327 PLAT
dbSNP Gene:5327 PLAT
ENSEMBL:ENSG00000104368 PLAT
ENSEMBL_homo_sapiens_GENE:ENSG00000104368.19 PLAT
HGNC:9051 PLAT
KEGG Gene (Homo sapiens):5327 PLAT
Monarch:5327 PLAT
NCBI Gene:5327 PLAT
OMIM:173370 PLAT
UCSC:P00750 PLAT
Reference Transcript
RefSeq:NM_033011.3 PLAT
RefSeq:NM_000930.4 PLAT
RefSeq:NM_001319189.1 PLAT
Other Identifiers
11715847_x_at
11732321_a_at
11747398_a_at
11747399_x_at
11749809_a_at
11753829_a_at
11754545_x_at
17076726
201860_PM_s_at
201860_s_at
3133234
3133235
3133236
3133241
3133242
3133244
3133245
3133246
3133247
3133248
3133249
3133251
3133252
3133254
3133256
3133257
3133259
3133260
3133263
3133264
3133269
33452_at
5327
8150509
A_23_P82868
GE80967
GE84488
GO:0001666
GO:0003824
GO:0004252
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006508
GO:0007596
GO:0008233
GO:0008236
GO:0009986
GO:0010757
GO:0014909
GO:0016787
GO:0022414
GO:0023052
GO:0030141
GO:0031410
GO:0031639
GO:0036211
GO:0042060
GO:0042730
GO:0043226
GO:0045177
GO:0045861
GO:0048008
GO:0048870
GO:0051219
GO:0051604
GO:0051918
GO:0060468
GO:0070062
GO:0097180
GO:0098685
GO:0098978
GO:0099183
GO:0110165
GO:0140096
HMNXSV003031863
ILMN_1738742
K03021_at
PH_hs_0014156
TC08001175.hg
TC08002306.hg
g4505860_3p_a_at
Participates
as an input of
crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Homo sapiens)
as a component of
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] (Homo sapiens)
as a member of
serine-type endopeptidases involved in novel PDGF processing [extracellular region] (Homo sapiens)
Other forms of this molecule
PLAT(311-562) [extracellular region]
PLAT(36-310) [extracellular region]
Inferred To
Plat [extracellular region]
(Mus musculus)
Plat [extracellular region]
(Rattus norvegicus)
PLAT [extracellular region]
(Bos taurus)
PLAT [extracellular region]
(Canis familiaris)
PLAT [extracellular region]
(Gallus gallus)
PLAT [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_127509.1
,
NP_000921.1
,
NP_001306118.1
Guide to Pharmacology - Targets
2392
OpenTargets
ENSG00000104368
ZINC - Substances
TPA_HUMAN
ZINC target
P00750
PRO
P00750
PDB
1PK2
,
1TPK
,
1TPG
,
1TPM
,
1PML
,
1RTF
,
1BDA
,
5BRR
,
5ZLZ
,
1TPN
,
1A5H
ZINC - Investigational
TPA_HUMAN
GeneCards
P00750
HPA
ENSG00000104368-PLAT
Ensembl
ENSP00000270188
,
ENSP00000220809
,
ENSP00000392045
,
ENSP00000504311
,
ENST00000220809
,
ENST00000352041
,
ENST00000429089
,
ENST00000679151
,
ENSG00000104368
Pharos - Targets
P00750
ZINC - Predictions - Purchasable
TPA_HUMAN
Orphanet
25493
HMDB Protein
HMDBP01868
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.527
2
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