Reactome | crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)

crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)

Stable Identifier

R-HSA-158781

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)

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The first step in the dissolution of a fibrin clot is the association of the one-chain form of tissue plasminogen activator with fibrin.

Literature References

PubMed ID	Title	Journal	Year
6433976	Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences Pohl, G, Kallstrom, M, Bergsdorf, N, Wallen, P, Jornvall, H	Biochemistry	1984
2962641	Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin Higgins, DL, Vehar, GA	Biochemistry	1987
7199524	Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. Hoylaerts, M, Rijken, DC, Lijnen, HR	J Biol Chem	1982