Reactome | PLAT(36-310) [extracellular region]

PLAT(36-310) [extracellular region]

Stable Identifier

R-HSA-158758

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

tissue plasminogen activator, heavy chain

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External Reference Information

External Reference

UniProt:P00750 PLAT

Gene Names

PLAT

Chain

signal peptide:1-22, propeptide:23-32, propeptide:33-35, chain:36-562, chain:36-310, chain:311-562

Reference Genes

BioGPS Gene:5327 PLAT

COSMIC (genes):PLAT PLAT

CTD Gene:5327 PLAT

dbSNP Gene:5327 PLAT

ENSEMBL:ENSG00000104368 PLAT

HGNC:9051 PLAT

KEGG:hsa:5327 PLAT

Monarch:5327 PLAT

NCBI Gene:5327 PLAT

OMIM:173370 PLAT

UCSC:P00750 PLAT

Reference Transcript

Other Identifiers

11715847_x_at

11732321_a_at

11747398_a_at

11747399_x_at

11749809_a_at

11753829_a_at

11754545_x_at

17076726

201860_PM_s_at

201860_s_at

3133234

3133235

3133236

3133241

3133242

3133243

3133244

3133245

3133246

3133247

3133248

3133249

3133250

3133251

3133252

3133253

3133254

3133255

3133256

3133257

3133258

3133259

3133260

3133263

3133264

3133265

3133269

33452_at

3431964

5327

8150509

A_23_P82868

GE80967

GE84488

GO:0001666

GO:0003824

GO:0004252

GO:0005102

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005786

GO:0006508

GO:0006617

GO:0007596

GO:0008236

GO:0009986

GO:0010757

GO:0014909

GO:0016787

GO:0023052

GO:0030141

GO:0031410

GO:0031639

GO:0036211

GO:0042730

GO:0043226

GO:0045177

GO:0045861

GO:0048008

GO:0048870

GO:0051219

GO:0051604

GO:0051918

GO:0060468

GO:0065003

GO:0070062

GO:0097180

GO:0098685

GO:0098978

GO:0099183

GO:0140096

HMNXSV003031863

ILMN_1738742

K03021_at

PH_hs_0014156

PH_hs_0039359

TC08001175.hg

TC08002306.hg

g4505860_3p_a_at

Participates

as a component of

tissue plasminogen activator (two-chain) [extracellular region] (Homo sapiens)

Other forms of this molecule

PLAT(36-562) [extracellular region]

PLAT(311-562) [extracellular region]

Inferred To

Plat [extracellular region] (Mus musculus)

Plat [extracellular region] (Rattus norvegicus)

PLAT [extracellular region] (Bos taurus)

PLAT [extracellular region] (Canis familiaris)

PLAT [extracellular region] (Gallus gallus)

PLAT [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000921.1, NP_001306118.1, NP_127509.1

Guide to Pharmacology - Targets

2392

OpenTargets

ENSG00000104368

ENSEMBL

ENST00000220809, ENST00000352041, ENSP00000220809, ENSP00000270188, ENST00000429089, ENSP00000504311, ENSP00000392045, ENST00000679151

ZINC - Substances

TPA_HUMAN

ZINC target

P00750

PRO

P00750

GlyGen

P00750

PDB

1TPN, 1TPM, 1RTF, 1PML, 1TPK, 1PK2, 1TPG, 1A5H, 1BDA, 5BRR, 5ZLZ

ZINC - Investigational

TPA_HUMAN

HPA

ENSG00000104368-PLAT

Pharos - Targets

P00750

Orphanet

PLAT

ZINC - Predictions - Purchasable

TPA_HUMAN

HMDB Protein

HMDBP01868

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2
UniProt:P05155 SERPING1	20	SERPING1 [platelet alpha granule lumen] (R-HSA-139868) SERPING1 L177P [endoplasmic reticulum lumen] (R-HSA-9650574) SERPING1 R400C [endoplasmic reticulum lumen] (R-HSA-9650511) SERPING1 V288E [endoplasmic reticulum lumen] (R-HSA-9650415) SERPING1 G184_P228del [endoplasmic reticulum lumen] (R-HSA-9650472) SERPING1 F236S [endoplasmic reticulum lumen] (R-HSA-9650538) SERPING1 T189N [endoplasmic reticulum lumen] (R-HSA-9650346) SERPING1 P476L [endoplasmic reticulum lumen] (R-HSA-9650563) SERPING1 G184R [endoplasmic reticulum lumen] (R-HSA-9650424) SERPING1 P489R [endoplasmic reticulum lumen] (R-HSA-9650330) SERPING1 S170P [endoplasmic reticulum lumen] (R-HSA-9650362) SERPING1 S280_P282del [endoplasmic reticulum lumen] (R-HSA-9650522) SERPING1 V473M [endoplasmic reticulum lumen] (R-HSA-9650331) SERPING1 N291H [endoplasmic reticulum lumen] (R-HSA-9650545) SERPING1 Q484* [endoplasmic reticulum lumen] (R-HSA-9650410) SERPING1 A2_M53del [endoplasmic reticulum lumen] (R-HSA-9651435) SERPING1 W482* [endoplasmic reticulum lumen] (R-HSA-9650502) SERPING1 Q338* [endoplasmic reticulum lumen] (R-HSA-9651424) SERPING1 I196N [endoplasmic reticulum lumen] (R-HSA-9651390) SERPING1 S36Ffs*21 [endoplasmic reticulum lumen] (R-HSA-9651423)	0.499	2