Reactome will be unavailable due to host maintenance from Friday, April 27 at 6pm to Sunday, April 29 at 11:55pm.

During the outage, you may wish to use our mirror site at reactome.ncpsb.org.

SERPINA1

Stable Identifier
R-HSA-141757
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Alpha-1-antitrypsin
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P01009 SERPINA1
Gene Names
SERPINA1, AAT, PI, PRO0684, PRO2209
Chain
signal peptide:1-24, chain:25-418, peptide:375-418
Reference Genes
BioGPS Gene:5265 SERPINA1
COSMIC (genes):SERPINA1 SERPINA1
CTD Gene:5265 SERPINA1
dbSNP Gene:5265 SERPINA1
ENSEMBL:ENSG00000197249 SERPINA1
HGNC:8941 SERPINA1
KEGG Gene (Homo sapiens):hsa:5265 SERPINA1
Monarch:5265 SERPINA1
NCBI Gene:5265 SERPINA1
OMIM:107400 SERPINA1
UCSC:P01009 SERPINA1
Reference Transcript
Other Identifiers
0001400452
11721454_a_at
11721455_s_at
11721456_x_at
11721457_a_at
1292
13211
16648
16796262
1ATU
1D5S
1EZX
1HP7
1IZ2
1KCT
1OO8
1OPH
1PSI
1QLP
1QMB
202833_s_at
211429_s_at
230318_at
2D26
2QUG
3577624
3577625
3577626
3577627
3577628
3577629
3577630
3577631
3577632
3577633
3577635
3577636
3577642
3577649
3577650
3577651
3577652
36781_at
3CWL
3CWM
3DRM
3DRU
3NDD
3NDF
3NE4
3T1P
4PYW
5265
5IO1
73396
7981068
7API
8API
927
9API
A0A024R6I7
A_23_P218111
A_33_P3289659
CAB013211
CAB016648
CAB073396
CCDS9925
E9KL23
ENSG00000197249
ENSP00000348068
ENSP00000376802
ENSP00000376803
ENSP00000385960
ENSP00000386094
ENSP00000390299
ENSP00000408474
ENSP00000416066
ENSP00000416354
ENSP00000451525
ENSP00000490054
ENST00000355814
ENST00000393087
ENST00000393088
ENST00000402629
ENST00000404814
ENST00000437397
ENST00000440909
ENST00000448921
ENST00000449399
ENST00000489769
ENST00000636712
EntrezGene:5265
g4505792_3p_a_at
GE62796
GO:0000139
GO:0002020
GO:0002576
GO:0004867
GO:0005515
GO:0005576
GO:0005578
GO:0005615
GO:0005783
GO:0005788
GO:0005794
GO:0006888
GO:0006953
GO:0007596
GO:0007599
GO:0010466
GO:0010951
GO:0030134
GO:0030414
GO:0031093
GO:0033116
GO:0042802
GO:0043231
GO:0043312
GO:0043687
GO:0044267
GO:0048208
GO:0070062
GO:1904813
HGNC:8941
HPA000927
HPA001292
Hs.297681.4.A1_3p_at
Hs.525557
ILMN_1686098
ILMN_1745961
ILMN_1764980
ILMN_2256050
ILMN_2338452
ILMN_2404154
K01396_at
MIM:107400
MIM:606963
MIM:613490
NM_000295
NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
NP_000286
NP_001002235
NP_001002236
NP_001121172
NP_001121173
NP_001121174
NP_001121175
NP_001121176
NP_001121177
NP_001121178
NP_001121179
PF00079
PH_hs_0028142
PH_hs_0036763
SERPINA1
SERPINA1-201
SERPINA1-202
SERPINA1-203
SERPINA1-204
SERPINA1-205
SERPINA1-206
SERPINA1-207
SERPINA1-208
SERPINA1-209
SERPINA1-210
SERPINA1-220
SM00093
TC14001466.hg
TC14002135.hg
uc001ycx.5
uc001ycy.5
uc001ycz.5
uc001yda.2
uc001ydc.5
uc010aux.3
uc010auy.3
uc010auz.4
uc010avb.3
uc059esj.1
UPI000000CBEC
UPI00001FDAB2
UPI0000408068
XM_017021370
XP_016876859
Participant Of
hasMember
Other forms of this molecule
SERPINA1 [platelet alpha granule lumen]
p-SERPINA1 [endoplasmic reticulum lumen]
SERPINA1 [endoplasmic reticulum lumen]
SERPINA1 [ficolin-1-rich granule lumen]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [COPII-coated ER to Golgi transport vesicle]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen]
Inferred To
Homologues of SERPINA1 [extracellular region] (Arabidopsis thaliana)
Homologues of SERPINA1 [extracellular region] (Danio rerio)
Homologues of SERPINA1 [extracellular region] (Gallus gallus)
Homologues of SERPINA1 [extracellular region] (Mus musculus)
Homologues of SERPINA1 [extracellular region] (Oryza sativa)
Homologues of SERPINA1 [extracellular region] (Rattus norvegicus)
Homologues of SERPINA1 [extracellular region] (Taeniopygia guttata)
Homologues of SERPINA1 [extracellular region] (Xenopus tropicalis)
SERPINA1 [extracellular region] (Arabidopsis thaliana)
SERPINA1 [extracellular region] (Bos taurus)
SERPINA1 [extracellular region] (Canis familiaris)
SERPINA1 [extracellular region] (Danio rerio)
SERPINA1 [extracellular region] (Gallus gallus)
SERPINA1 [extracellular region] (Mus musculus)
SERPINA1 [extracellular region] (Oryza sativa)
SERPINA1 [extracellular region] (Rattus norvegicus)
SERPINA1 [extracellular region] (Sus scrofa)
SERPINA1 [extracellular region] (Taeniopygia guttata)
SERPINA1 [extracellular region] (Xenopus tropicalis)
Cross References
RefSeq
Brenda
GeneCards
DOCK Blaster
PRO
Orphanet
PDB
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P43307 SSR1  1 0.524 4