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SERPINA1 [extracellular region]
Stable Identifier
R-HSA-141757
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Alpha-1-antitrypsin
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
SERPINA1 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
SERPINA1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01009 SERPINA1
Gene Names
SERPINA1, AAT, PI, PRO0684, PRO2209
Chain
signal peptide:1-24, chain:25-418, peptide:375-418
Reference Genes
BioGPS Gene:5265 SERPINA1
COSMIC (genes):SERPINA1 SERPINA1
CTD Gene:5265 SERPINA1
dbSNP Gene:5265 SERPINA1
ENSEMBL:ENSG00000197249 SERPINA1
HGNC:8941 SERPINA1
KEGG Gene (Homo sapiens):5265 SERPINA1
Monarch:5265 SERPINA1
NCBI Gene:5265 SERPINA1
OMIM:107400 SERPINA1
UCSC:P01009 SERPINA1
Reference Transcript
RefSeq:NM_001002236.2 SERPINA1
RefSeq:NM_001127704.1 SERPINA1
RefSeq:NM_001127700.1 SERPINA1
RefSeq:NM_001127705.1 SERPINA1
RefSeq:NM_001127702.1 SERPINA1
RefSeq:NM_001127707.1 SERPINA1
RefSeq:NM_001127701.1 SERPINA1
RefSeq:NM_001127706.1 SERPINA1
RefSeq:NM_001002235.2 SERPINA1
RefSeq:NM_001127703.1 SERPINA1
RefSeq:XM_017021370.1 SERPINA1
RefSeq:NM_000295.4 SERPINA1
Other Identifiers
0001400452
11721454_a_at
11721455_s_at
11721456_x_at
11721457_a_at
16796262
202833_s_at
211429_s_at
230318_at
3577624
3577625
3577626
3577627
3577628
3577629
3577630
3577631
3577632
3577633
3577635
3577636
3577642
3577649
3577651
3577652
36781_at
5265
7981068
A_23_P218111
A_33_P3289659
GE62796
GO:0002020
GO:0002376
GO:0002576
GO:0003674
GO:0004867
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005794
GO:0006464
GO:0006810
GO:0006888
GO:0006950
GO:0006953
GO:0007596
GO:0007599
GO:0008150
GO:0010466
GO:0010951
GO:0016192
GO:0019899
GO:0022607
GO:0030134
GO:0030234
GO:0030414
GO:0031012
GO:0031093
GO:0031410
GO:0033116
GO:0042802
GO:0043226
GO:0043231
GO:0043312
GO:0043687
GO:0044267
GO:0048208
GO:0061024
GO:0062023
GO:0065003
GO:0070062
GO:1904813
HMNXSV003030416
HMNXSV003046236
Hs.297681.4.A1_3p_at
ILMN_1686098
ILMN_1745961
ILMN_2256050
ILMN_2338452
ILMN_2404154
K01396_at
PH_hs_0028142
PH_hs_0036763
TC14001466.hg
TC14002135.hg
g4505792_3p_a_at
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
SERPINA1 [platelet alpha granule lumen]
SERPINA1 [ficolin-1-rich granule lumen]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [COPII-coated ER to Golgi transport vesicle]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen]
p-SERPINA1 [endoplasmic reticulum lumen]
SERPINA1 [endoplasmic reticulum lumen]
Inferred To
Spn42Da [extracellular region]
(Drosophila melanogaster)
Spn28Dc [extracellular region]
(Drosophila melanogaster)
SPIA1 [extracellular region]
(Gallus gallus)
Spn88Eb [extracellular region]
(Drosophila melanogaster)
SPIA9 [extracellular region]
(Gallus gallus)
Spn27A [extracellular region]
(Drosophila melanogaster)
Serpina1c [extracellular region]
(Mus musculus)
SPIA5 [extracellular region]
(Gallus gallus)
Spn42Dd [extracellular region]
(Drosophila melanogaster)
srp-8 [extracellular region]
(Caenorhabditis elegans)
srp-7 [extracellular region]
(Caenorhabditis elegans)
Spn42Db [extracellular region]
(Drosophila melanogaster)
SPIA4 [extracellular region]
(Gallus gallus)
Homologues of SERPINA1 [extracellular region]
(Caenorhabditis elegans)
Homologues of SERPINA1 [extracellular region]
(Danio rerio)
Homologues of SERPINA1 [extracellular region]
(Drosophila melanogaster)
Homologues of SERPINA1 [extracellular region]
(Gallus gallus)
Homologues of SERPINA1 [extracellular region]
(Sus scrofa)
Homologues of SERPINA1 [extracellular region]
(Xenopus tropicalis)
Spn43Ab [extracellular region]
(Drosophila melanogaster)
Spn53F [extracellular region]
(Drosophila melanogaster)
Spn88Ea [extracellular region]
(Drosophila melanogaster)
serpina1l [extracellular region]
(Danio rerio)
LOC110439158 [extracellular region]
(Danio rerio)
serpina3k [extracellular region]
(Xenopus tropicalis)
Spn38F [extracellular region]
(Drosophila melanogaster)
serpina7 [extracellular region]
(Danio rerio)
srp-3 [extracellular region]
(Caenorhabditis elegans)
Spn42Dc [extracellular region]
(Drosophila melanogaster)
SERPINA1 [extracellular region]
(Bos taurus)
SERPINA1 [extracellular region]
(Caenorhabditis elegans)
SERPINA1 [extracellular region]
(Canis familiaris)
SERPINA1 [extracellular region]
(Danio rerio)
SERPINA1 [extracellular region]
(Sus scrofa)
SERPINA1 [extracellular region]
(Xenopus tropicalis)
serpina3 [extracellular region]
(Xenopus tropicalis)
Spn28B [extracellular region]
(Drosophila melanogaster)
Spn28F [extracellular region]
(Drosophila melanogaster)
Serpina1 [extracellular region]
(Rattus norvegicus)
srp-6 [extracellular region]
(Caenorhabditis elegans)
Spn28Da [extracellular region]
(Drosophila melanogaster)
SPIA3 [extracellular region]
(Gallus gallus)
LOC100621494 [extracellular region]
(Sus scrofa)
srp-2 [extracellular region]
(Caenorhabditis elegans)
Spn100A [extracellular region]
(Drosophila melanogaster)
Spn43Aa [extracellular region]
(Drosophila melanogaster)
Spn47C [extracellular region]
(Drosophila melanogaster)
si:ch211-186e20.2 [extracellular region]
(Danio rerio)
Dmel\CG43366 [extracellular region]
(Drosophila melanogaster)
Spn28Db [extracellular region]
(Drosophila melanogaster)
Spn55B [extracellular region]
(Drosophila melanogaster)
nec [extracellular region]
(Drosophila melanogaster)
Spn31A [extracellular region]
(Drosophila melanogaster)
serpina3m [extracellular region]
(Xenopus tropicalis)
srp-1 [extracellular region]
(Caenorhabditis elegans)
serpina1 [extracellular region]
(Danio rerio)
Spn42De [extracellular region]
(Drosophila melanogaster)
si:ch211-186e20.7 [extracellular region]
(Danio rerio)
Spn43Ad [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001121175.1
,
NP_000286.3
,
XP_016876859.1
,
NP_001121176.1
,
NP_001121172.1
,
NP_001002235.1
,
NP_001121178.1
,
NP_001002236.1
,
NP_001121177.1
,
NP_001121174.1
,
NP_001121179.1
,
NP_001121173.1
OpenTargets
ENSG00000197249
GeneCards
P01009
HPA
ENSG00000197249-SERPINA1
Ensembl
ENSP00000376803
,
ENSP00000385960
,
ENSP00000348068
,
ENSP00000386094
,
ENSP00000490054
,
ENSP00000376802
,
ENST00000636712
,
ENSP00000451525
,
ENST00000448921
,
ENST00000489769
,
ENSP00000408474
,
ENST00000449399
,
ENST00000355814
,
ENST00000437397
,
ENSP00000416066
,
ENSG00000197249
,
ENST00000393087
,
ENST00000393088
,
ENST00000402629
,
ENSP00000416354
,
ENSP00000390299
,
ENST00000440909
,
ENST00000404814
PRO
P01009
Pharos - Targets
P01009
GlyGen
P01009
Orphanet
15271
PDB
3T1P
,
7API
,
1D5S
,
5IO1
,
3NDF
,
6HX4
,
4PYW
,
1EZX
,
1KCT
,
2D26
,
1OPH
,
7NPK
,
5NBU
,
9API
,
3NE4
,
6ROD
,
6I4V
,
6IAY
,
1IZ2
,
1QLP
,
7NPL
,
2QUG
,
1OO8
,
3DRM
,
5NBV
,
1PSI
,
3CWL
,
1ATU
,
7AEL
,
1QMB
,
3CWM
,
3NDD
,
8API
,
3DRU
,
6I7U
,
1HP7
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15393 TMPRSS2
2
TMPRSS2 [extracellular region]
(R-HSA-9681528)
TMPRSS2 [plasma membrane]
(R-HSA-9686707)
0.558
2
UniProt:P43307 SSR1
1
SSR1 [endoplasmic reticulum membrane]
(R-HSA-444588)
0.524
4
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