Reactome | ELANE [azurophil granule lumen]

ELANE [azurophil granule lumen]

Stable Identifier

R-HSA-6799238

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Neutrophil elastase, ELA2, ELNE_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08246 ELANE

Gene Names

ELANE, ELA2

Chain

signal peptide:1-27, propeptide:28-29, chain:30-267

Reference Genes

BioGPS Gene:1991 ELANE

COSMIC (genes):ELANE ELANE

CTD Gene:1991 ELANE

dbSNP Gene:1991 ELANE

ENSEMBL:ENSG00000197561 ELANE

HGNC:3309 ELANE

KEGG:hsa:1991 ELANE

Monarch:1991 ELANE

NCBI Gene:1991 ELANE

OMIM:130130 ELANE

UCSC:P08246 ELANE

Reference Transcript

Other Identifiers

11727965_at

16856292

1991

206871_PM_at

206871_at

37096_at

3815234

3815235

3815236

3815237

3815238

3815239

3815240

3815241

3815242

8024056

A_14_P112290

A_23_P130961

GO:0000122

GO:0001878

GO:0002020

GO:0002376

GO:0002438

GO:0002523

GO:0002812

GO:0003714

GO:0004175

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005794

GO:0005829

GO:0006355

GO:0006508

GO:0006874

GO:0006909

GO:0006954

GO:0008201

GO:0008233

GO:0008236

GO:0009411

GO:0009986

GO:0016192

GO:0016787

GO:0017053

GO:0019955

GO:0022617

GO:0030141

GO:0030163

GO:0030198

GO:0030312

GO:0031012

GO:0031410

GO:0032496

GO:0032682

GO:0032717

GO:0032757

GO:0035578

GO:0035580

GO:0042742

GO:0043406

GO:0045335

GO:0048661

GO:0048870

GO:0050728

GO:0050778

GO:0050832

GO:0050900

GO:0050922

GO:0070062

GO:0070269

GO:0070945

GO:0070947

GO:0098542

GO:1903238

HMNXSV003020870

ILMN_1706635

M20203_s_at

M27783_s_at

PH_hs_0005576

TC19000019.hg

Y00477_at

g4503548_3p_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

ELANE [extracellular region]

ELANE [cytosol]

ELANE [specific granule lumen]

Inferred To

ELA2 [azurophil granule lumen] (Bos taurus)

ELA2 [azurophil granule lumen] (Canis familiaris)

ELANE [azurophil granule lumen] (Sus scrofa)

Elane [azurophil granule lumen] (Mus musculus)

Elane [azurophil granule lumen] (Rattus norvegicus)

prtn3 [azurophil granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001963.1, XP_054185414.1, XP_054176121.1, XP_054185415.1, XP_054176122.1, XP_011526078.1, XP_011526077.1

ZINC - World Drugs

ELNE_HUMAN

Guide to Pharmacology - Targets

2358

OpenTargets

ENSG00000197561

ENSEMBL

ENSG00000277571, ENSP00000488075, ENSG00000197561, ENST00000590230, ENSP00000263621, ENST00000632488, ENST00000615489, ENST00000263621, ENSP00000480128, ENSP00000466090

ZINC - FDA approved

ELNE_HUMAN

ZINC - Substances

ELNE_HUMAN

ZINC - Biogenic

ELNE_HUMAN

ZINC target

P08246

PRO

P08246

PDB

8D4U, 1HNE, 2RG3, 1B0F, 9ASS, 6F5M, 8QGX, 8D7K, 5ABW, 5A0A, 5A09, 7CBK, 8G25, 5A0C, 5A0B, 8D7I, 4NZL, 6E69, 8G24, 5A8X, 8G26, 5A8Y, 3Q76, 5A8Z, 9ASX, 7WHU, 4WVP, 3Q77, 9ATK, 2Z7F, 8D4Q, 9ATU, 8VK5, 6SMA, 1PPF, 1PPG, 1H1B

ZINC - Investigational

ELNE_HUMAN

IntEnz

3.4.21.37

HPA

ENSG00000197561-ELANE

GeneCards

ELANE

Pharos - Targets

P08246

Orphanet

ELANE

ZINC - Predictions - Purchasable

ELNE_HUMAN

HMDB Protein

HMDBP13378

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01009 SERPINA1	8	SERPINA1 [platelet alpha granule lumen] (R-HSA-141755) SERPINA1 [extracellular region] (R-HSA-141757) SERPINA1 [endoplasmic reticulum lumen] (R-HSA-8956709) p-SERPINA1 [endoplasmic reticulum lumen] (R-HSA-8957062) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (R-HSA-5689435) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689731) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689734) SERPINA1 [ficolin-1-rich granule lumen] (R-HSA-6804783)	0.59	2
UniProt:P19823 ITIH2	2	p-ITIH2 [endoplasmic reticulum lumen] (R-HSA-8956974) ITIH2 [endoplasmic reticulum lumen] (R-HSA-8956783)	0.527	2